ITPKA - Inositol-trisphosphate 3-kinase A - human protein (Function)
 
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ITPKA »  Inositol-trisphosphate 3-kinase A   [ EC 2.7.1.127 ]
 
Protein also known as:  Inositol 1,4,5-trisphosphate 3-kinase A (IP3K A).
Gene name:  ITPKA
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Calmodulin bindingdefinition[GO:0005516]  
  • IEAUniProtKB KW
Calmodulin-dependent protein kinase activitydefinition[GO:0004683] silver  
  • IEAOrtholog Compara
Inositol-1,4,5-trisphosphate 3-kinase activitydefinition[GO:0008440]  
  • IEAEC 2 GO
Rac GTPase bindingdefinition[GO:0048365] silver  
  • IEAOrtholog Compara
GO biological process 
Actin cytoskeleton organizationdefinition[GO:0030036] silver  
  • IEAOrtholog Compara
Dendritic spine maintenancedefinition[GO:0097062] silver  
  • IEAOrtholog Compara
Inositol metabolic processdefinition[GO:0006020] silver  
  • IEAOrtholog Compara
Positive regulation of dendritic spine morphogenesisdefinition[GO:0061003] silver  
  • IEAOrtholog Compara
Protein phosphorylationdefinition[GO:0006468]  
  • IEAOrtholog Compara
Regulation of synaptic plasticitydefinition[GO:0048167] silver  
  • IEAOrtholog Compara
Signal transductiondefinition[GO:0007165]  
2
  • TASPINC
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.1.127: ATP + 1D-myo-inositol 1,4,5-trisphosphate ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate.  
  • CuratedUniProtKB
It is regulated in the following manner
IP3K is activated by calmodulin.  
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Calcium signaling pathway  hsa04020+3706  
Inositol phosphate metabolism  hsa00562+3706  
Metabolic pathways  hsa01100+3706  
Phosphatidylinositol signaling system  hsa04070+3706  
According to Reactome, this protein belongs to the following pathway:
Synthesis of IP3 and IP4 in the cytosol  REACT_150312  
 
More information is available from:
 

Keywords

Molecular function 
Kinase  definition   [KW-0418]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ITPKA
GenomeRNAi: 3706
PRO: PR:P23677