GATA2 - Endothelial transcription factor GATA-2 - human protein (Function)
 
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Protein
Gene
References

 
GATA2 »  Endothelial transcription factor GATA-2
 
Protein also known as:  GATA-binding protein 2.
Gene name:  GATA2
Entry whose protein(s) existence is based on evidence at protein level
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1 146 2
GENE REF ISO

Function

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Overview 
Transcriptional activator which regulates endothelin-1 gene expression in endothelial cells. Binds to the consensus sequence 5'-AGATAG-3'.  
1
  • UniProtKB
GO molecular function 
C2H2 zinc finger domain bindingdefinition[GO:0070742]  
1
  • BHF-UCL
Chromatin bindingdefinition[GO:0003682]  
1
  • MGI
Enhancer sequence-specific DNA bindingdefinition[GO:0001158]  
1
  • MGI
Protein bindingdefinition[GO:0005515]  
7
  • IntAct
  • UniProtKB
RNA polymerase II distal enhancer sequence-specific DNA bindingdefinition[GO:0000980] silver  
1
  • Ortholog Compara
RNA polymerase II regulatory region sequence-specific DNA bindingdefinition[GO:0000977]  
1
  • RefGenome
RNA polymerase II transcription factor bindingdefinition[GO:0001085]  
1
  • RefGenome
Transcription factor activity, sequence-specific DNA bindingdefinition[GO:0003700]  
2
  • UniProtKB
  • BHF-UCL
Transcription factor bindingdefinition[GO:0008134]  
1
  • BHF-UCL
Transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific bindingdefinition[GO:0001077] silver  
1
  • Ortholog Compara
Transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific bindingdefinition[GO:0001228]  
1
  • RefGenome
Zinc ion bindingdefinition[GO:0008270] silver  
1
  • InterPro 2 GO
GO biological process 
Cell differentiation in hindbraindefinition[GO:0021533] silver  
1
  • Ortholog Compara
Cell fate determinationdefinition[GO:0001709] silver  
1
  • Ortholog Compara
Cell maturationdefinition[GO:0048469] silver  
1
  • Ortholog Compara
Central nervous system neuron developmentdefinition[GO:0021954] silver  
1
  • Ortholog Compara
Commitment of neuronal cell to specific neuron type in forebraindefinition[GO:0021902] silver  
1
  • Ortholog Compara
Definitive hemopoiesisdefinition[GO:0060216] silver  
1
  • Ortholog Compara
Digestive tract developmentdefinition[GO:0048565]  
1
  • RefGenome
Embryonic placenta developmentdefinition[GO:0001892] silver  
1
  • Ortholog Compara
Eosinophil fate commitmentdefinition[GO:0035854]  
1
  • BHF-UCL
GABAergic neuron differentiationdefinition[GO:0097154] silver  
1
  • Ortholog Compara
Heart developmentdefinition[GO:0007507]  
1
  • RefGenome
Homeostasis of number of cells within a tissuedefinition[GO:0048873] silver  
1
  • Ortholog Compara
Inner ear morphogenesisdefinition[GO:0042472] silver  
1
  • Ortholog Compara
Mast cell degranulationdefinition[GO:0043303] silver  
1
  • Ortholog Compara
Negative regulation of fat cell differentiationdefinition[GO:0045599]  
1
  • UniProtKB
Negative regulation of fat cell proliferationdefinition[GO:0070345]  
1
  • UniProtKB
Negative regulation of macrophage differentiationdefinition[GO:0045650] silver  
1
  • Ortholog Compara
Negative regulation of neural precursor cell proliferationdefinition[GO:2000178]  
1
  • MGI
Negative regulation of Notch signaling pathwaydefinition[GO:0045746]  
1
  • MGI
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122] silver  
1
  • Ortholog Compara
Neuron migrationdefinition[GO:0001764] silver  
1
  • Ortholog Compara
Organ morphogenesisdefinition[GO:0009887]  
1
  • RefGenome
Phagocytosisdefinition[GO:0006909]  
1
  • UniProtKB KW
Pituitary gland developmentdefinition[GO:0021983] silver  
1
  • Ortholog Compara
Positive regulation of angiogenesisdefinition[GO:0045766]  
1
  • MGI
Positive regulation of cytosolic calcium ion concentrationdefinition[GO:0007204] silver  
1
  • Ortholog Compara
Positive regulation of erythrocyte differentiationdefinition[GO:0045648] silver  
1
  • Ortholog Compara
Positive regulation of megakaryocyte differentiationdefinition[GO:0045654] silver  
1
  • Ortholog Compara
Positive regulation of neuron differentiationdefinition[GO:0045666] silver  
1
  • Ortholog Compara
Positive regulation of phagocytosisdefinition[GO:0050766]  
1
  • Ortholog Curator
Positive regulation of phagocytosis, engulfmentdefinition[GO:0060100] silver  
1
  • Ortholog Compara
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
4
  • UniProtKB
  • MGI
  • BHF-UCL
Regulation of forebrain neuron differentiationdefinition[GO:2000977] silver  
1
  • Ortholog Compara
Regulation of histone acetylationdefinition[GO:0035065] silver  
1
  • Ortholog Compara
Response to lipiddefinition[GO:0033993] silver  
1
  • Ortholog Compara
Semicircular canal developmentdefinition[GO:0060872] silver  
1
  • Ortholog Compara
Somatic stem cell population maintenancedefinition[GO:0035019] silver  
1
  • Ortholog Compara
Tissue developmentdefinition[GO:0009888]  
1
  • RefGenome
Transcription from RNA polymerase II promoterdefinition[GO:0006366] silver  
1
  • Ortholog Compara
Transcription, DNA-templateddefinition[GO:0006351]  
1
  • UniProtKB
Urogenital system developmentdefinition[GO:0001655] silver  
1
  • Ortholog Compara
Ventral spinal cord interneuron differentiationdefinition[GO:0021514] silver  
1
  • Ortholog Compara
Pathways 
According to Reactome, this protein belongs to the following pathway:
Factors involved in megakaryocyte development and platelet production  R-HSA-983231  
 

Keywords

Biological process 
Phagocytosis  definition   [KW-0581]
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Activator  definition   [KW-0010]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: GATA2
GenomeRNAi: 2624
PRO: PR:P23769