GATA2 - Endothelial transcription factor GATA-2 - human protein (Function)
 
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GATA2 »  Endothelial transcription factor GATA-2
 
Protein also known as:  GATA-binding protein 2.
Gene name:  GATA2
Entry whose protein(s) existence is based on evidence at protein level
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1 106 2
GENE REF ISO

Function

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Overview 
Transcriptional activator which regulates endothelin-1 gene expression in endothelial cells. Binds to the consensus sequence 5'-AGATAG-3'.  
  • CuratedUniProtKB
GO molecular function 
C2H2 zinc finger domain bindingdefinition[GO:0070742]  
1
  • IPIBHF-UCL
Chromatin bindingdefinition[GO:0003682]  
1
  • IDAMGI
Enhancer sequence-specific DNA bindingdefinition[GO:0001158]  
1
  • IDAMGI
Protein bindingdefinition[GO:0005515]  
5
  • IPIIntAct
  • IPIUniProtKB
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptiondefinition[GO:0001077] silver  
  • IEAOrtholog Compara
RNA polymerase II distal enhancer sequence-specific DNA bindingdefinition[GO:0000980] silver  
  • IEAOrtholog Compara
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700]  
2
  • IDAUniProtKB
  • IDABHF-UCL
Transcription factor bindingdefinition[GO:0008134]  
1
  • IPIBHF-UCL
Zinc ion bindingdefinition[GO:0008270] silver  
  • IEAInterPro 2 GO
GO biological process 
Cell differentiation in hindbraindefinition[GO:0021533] silver  
  • IEAOrtholog Compara
Cell fate determinationdefinition[GO:0001709] silver  
  • IEAOrtholog Compara
Cell maturationdefinition[GO:0048469] silver  
  • IEAOrtholog Compara
Central nervous system neuron developmentdefinition[GO:0021954] silver  
  • IEAOrtholog Compara
Definitive hemopoiesisdefinition[GO:0060216] silver  
  • IEAOrtholog Compara
Embryonic placenta developmentdefinition[GO:0001892] silver  
  • IEAOrtholog Compara
Eosinophil fate commitmentdefinition[GO:0035854]  
1
  • IDABHF-UCL
Homeostasis of number of cells within a tissuedefinition[GO:0048873] silver  
  • IEAOrtholog Compara
Inner ear morphogenesisdefinition[GO:0042472] silver  
  • IEAOrtholog Compara
Negative regulation of fat cell differentiationdefinition[GO:0045599]  
1
  • IMPUniProtKB
Negative regulation of fat cell proliferationdefinition[GO:0070345]  
1
  • IMPUniProtKB
Negative regulation of macrophage differentiationdefinition[GO:0045650] silver  
  • IEAOrtholog Compara
Negative regulation of neural precursor cell proliferationdefinition[GO:2000178]  
1
  • IDAMGI
Negative regulation of Notch signaling pathwaydefinition[GO:0045746]  
1
  • IDAMGI
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122] silver  
  • IEAOrtholog Compara
Neuron fate commitmentdefinition[GO:0048663] silver  
  • IEAOrtholog Compara
Phagocytosisdefinition[GO:0006909] silver  
  • IEAOrtholog Compara
Pituitary gland developmentdefinition[GO:0021983] silver  
  • IEAOrtholog Compara
Positive regulation of angiogenesisdefinition[GO:0045766]  
1
  • IDAMGI
Positive regulation of erythrocyte differentiationdefinition[GO:0045648] silver  
  • IEAOrtholog Compara
Positive regulation of megakaryocyte differentiationdefinition[GO:0045654] silver  
  • IEAOrtholog Compara
Positive regulation of phagocytosisdefinition[GO:0050766]  
  • ISSOrtholog Curator
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
4
  • IDAUniProtKB
  • IGIMGI
  • IDABHF-UCL
Regulation of histone acetylationdefinition[GO:0035065] silver  
  • IEAOrtholog Compara
Semicircular canal developmentdefinition[GO:0060872] silver  
  • IEAOrtholog Compara
Somatic stem cell maintenancedefinition[GO:0035019] silver  
  • IEAOrtholog Compara
Transcription, DNA-templateddefinition[GO:0006351]  
1
  • IDAUniProtKB
Urogenital system developmentdefinition[GO:0001655] silver  
  • IEAOrtholog Compara
Ventral spinal cord interneuron differentiationdefinition[GO:0021514] silver  
  • IEAOrtholog Compara
Pathways 
According to Reactome, this protein belongs to the following pathway:
Factors involved in megakaryocyte development and platelet production  REACT_24970  
 

Keywords

Biological process 
Phagocytosis  definition   [KW-0581]
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Activator  definition   [KW-0010]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: GATA2
GenomeRNAi: 2624
PRO: PR:P23769