GATA3 - Trans-acting T-cell-specific transcription factor GATA-3 - human protein (Function)
 
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GATA3 »  Trans-acting T-cell-specific transcription factor GATA-3
 
Protein also known as:  GATA-binding factor 3.
Gene name:  GATA3
Entry whose protein(s) existence is based on evidence at protein level
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1 219 2
GENE REF ISO

Function

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Overview 
Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5'-AGATAG-3'. Required for the T-helper 2 (Th2) differentiation process following immune and inflammatory responses.  
2
  • UniProtKB
GO molecular function 
Core promoter proximal region sequence-specific DNA bindingdefinition[GO:0000987]  
1
  • UniProtKB
Core promoter sequence-specific DNA bindingdefinition[GO:0001046]  
1
  • UniProtKB
DNA bindingdefinition[GO:0003677]  
1
  • PINC
E-box bindingdefinition[GO:0070888]  
1
  • BHF-UCL
Enhancer sequence-specific DNA bindingdefinition[GO:0001158] silver  
1
  • Ortholog Compara
HMG box domain bindingdefinition[GO:0071837]  
1
  • UniProtKB
Interleukin-2 receptor bindingdefinition[GO:0005134] silver  
1
  • Ortholog Compara
Nucleic acid binding transcription factor activitydefinition[GO:0001071]  
5
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
4
  • IntAct
  • UniProtKB
Protein dimerization activitydefinition[GO:0046983] silver  
1
  • Ortholog Compara
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcriptiondefinition[GO:0001078]  
1
  • UniProtKB
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptiondefinition[GO:0001077] silver  
1
  • Ortholog Compara
RNA polymerase II core promoter sequence-specific DNA bindingdefinition[GO:0000979] silver  
1
  • Ortholog Compara
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700]  
2
  • PINC
Transcription coactivator activitydefinition[GO:0003713]  
1
  • UniProtKB
Transcription factor bindingdefinition[GO:0008134]  
1
  • BHF-UCL
Transcription regulatory region DNA bindingdefinition[GO:0044212]  
4
  • UniProtKB
Transcription regulatory region sequence-specific DNA bindingdefinition[GO:0000976]  
1
  • UniProtKB
Zinc ion bindingdefinition[GO:0008270] silver  
1
  • InterPro 2 GO
GO biological process 
Anatomical structure formation involved in morphogenesisdefinition[GO:0048646]  
1
  • Ortholog Curator
Anatomical structure morphogenesisdefinition[GO:0009653]  
1
  • PINC
Aortic valve morphogenesisdefinition[GO:0003180]  
1
  • Ortholog Curator
Axon guidancedefinition[GO:0007411] silver  
1
  • Ortholog Compara
Canonical Wnt signaling pathway involved in metanephric kidney developmentdefinition[GO:0061290]  
1
  • Ortholog Curator
Cardiac right ventricle morphogenesisdefinition[GO:0003215]  
1
  • Ortholog Curator
Cell fate determinationdefinition[GO:0001709]  
1
  • Ortholog Curator
Cell maturationdefinition[GO:0048469] silver  
1
  • Ortholog Compara
Cellular response to BMP stimulusdefinition[GO:0071773] silver  
1
  • Ortholog Compara
Cellular response to interferon-alphadefinition[GO:0035457]  
1
  • UniProtKB
Cellular response to interleukin-4definition[GO:0071353]  
1
  • UniProtKB
Cellular response to tumor necrosis factordefinition[GO:0071356]  
1
  • UniProtKB
Defense responsedefinition[GO:0006952]  
1
  • PINC
Developmental growthdefinition[GO:0048589] silver  
1
  • Ortholog Compara
Ear developmentdefinition[GO:0043583]  
2
  • UniProtKB
Embryonic hemopoiesisdefinition[GO:0035162] silver  
1
  • Ortholog Compara
Erythrocyte differentiationdefinition[GO:0030218] silver  
1
  • Ortholog Compara
Humoral immune responsedefinition[GO:0006959] silver  
1
  • Ortholog Compara
In utero embryonic developmentdefinition[GO:0001701] silver  
1
  • Ortholog Compara
Innate immune responsedefinition[GO:0045087]  
1
  • UniProtKB KW
Inner ear morphogenesisdefinition[GO:0042472] silver  
1
  • Ortholog Compara
Interferon-gamma secretiondefinition[GO:0072643] silver  
1
  • Ortholog Compara
Interleukin-4 secretiondefinition[GO:0072602] silver  
1
  • Ortholog Compara
Kidney developmentdefinition[GO:0001822]  
2
  • UniProtKB
Lens development in camera-type eyedefinition[GO:0002088] silver  
1
  • Ortholog Compara
Lymphocyte migrationdefinition[GO:0072676]  
1
  • UniProtKB
Male gonad developmentdefinition[GO:0008584]  
1
  • Ortholog Curator
Mast cell differentiationdefinition[GO:0060374] silver  
1
  • Ortholog Compara
Mesenchymal to epithelial transitiondefinition[GO:0060231]  
1
  • UniProtKB
Mesonephros developmentdefinition[GO:0001823]  
1
  • Ortholog Curator
Negative regulation of cell cycledefinition[GO:0045786]  
1
  • UniProtKB
Negative regulation of cell motilitydefinition[GO:2000146]  
1
  • UniProtKB
Negative regulation of cell proliferationdefinition[GO:0008285]  
1
  • Ortholog Curator
Negative regulation of cell proliferation involved in mesonephros developmentdefinition[GO:2000607]  
1
  • Ortholog Curator
Negative regulation of endothelial cell apoptotic processdefinition[GO:2000352]  
1
  • UniProtKB
Negative regulation of fat cell differentiationdefinition[GO:0045599]  
1
  • UniProtKB
Negative regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formationdefinition[GO:2000703]  
1
  • Ortholog Curator
Negative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formationdefinition[GO:2000734]  
1
  • Ortholog Curator
Negative regulation of inflammatory responsedefinition[GO:0050728]  
1
  • UniProtKB
Negative regulation of interferon-gamma productiondefinition[GO:0032689] silver  
1
  • Ortholog Compara
Negative regulation of interleukin-2 productiondefinition[GO:0032703] silver  
1
  • Ortholog Compara
Negative regulation of mammary gland epithelial cell proliferationdefinition[GO:0033600]  
1
  • UniProtKB
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122] silver  
1
  • Ortholog Compara
Negative regulation of transcription, DNA-templateddefinition[GO:0045892]  
1
  • UniProtKB
Nephric duct formationdefinition[GO:0072179]  
1
  • Ortholog Curator
Nephric duct morphogenesisdefinition[GO:0072178]  
1
  • Ortholog Curator
Neuron migrationdefinition[GO:0001764] silver  
1
  • Ortholog Compara
Norepinephrine biosynthetic processdefinition[GO:0042421]  
1
  • Ortholog Curator
Otic vesicle developmentdefinition[GO:0071599] silver  
1
  • Ortholog Compara
Parathyroid gland developmentdefinition[GO:0060017] silver  
1
  • Ortholog Compara
Parathyroid hormone secretiondefinition[GO:0035898] silver  
1
  • Ortholog Compara
Pharyngeal system developmentdefinition[GO:0060037]  
1
  • Ortholog Curator
Phosphatidylinositol 3-kinase signalingdefinition[GO:0014065]  
1
  • Ortholog Curator
Positive regulation of endothelial cell migrationdefinition[GO:0010595]  
1
  • UniProtKB
Positive regulation of interleukin-13 secretiondefinition[GO:2000667]  
2
  • UniProtKB
Positive regulation of interleukin-4 productiondefinition[GO:0032753]  
1
  • Ortholog Curator
Positive regulation of interleukin-5 secretiondefinition[GO:2000664]  
1
  • UniProtKB
Positive regulation of protein kinase B signalingdefinition[GO:0051897]  
1
  • UniProtKB
Positive regulation of signal transductiondefinition[GO:0009967]  
1
  • UniProtKB
Positive regulation of T cell differentiationdefinition[GO:0045582]  
1
  • Ortholog Curator
Positive regulation of thyroid hormone generationdefinition[GO:2000611]  
2
  • UniProtKB
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
5
  • BHF-UCL
  • UniProtKB
  • Ortholog Curator
Positive regulation of transcription regulatory region DNA bindingdefinition[GO:2000679]  
1
  • UniProtKB
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
5
  • UniProtKB
  • Ortholog Curator
Positive regulation of ureteric bud formationdefinition[GO:0072107]  
1
  • Ortholog Curator
Post-embryonic developmentdefinition[GO:0009791] silver  
1
  • Ortholog Compara
Pro-T cell differentiationdefinition[GO:0002572] silver  
1
  • Ortholog Compara
Regulation of CD4-positive, alpha-beta T cell differentiationdefinition[GO:0043370] silver  
1
  • Ortholog Compara
Regulation of cellular response to X-raydefinition[GO:2000683]  
1
  • UniProtKB
Regulation of cytokine biosynthetic processdefinition[GO:0042035]  
1
  • Ortholog Curator
Regulation of establishment of cell polaritydefinition[GO:2000114] silver  
1
  • Ortholog Compara
Regulation of histone H3-K27 methylationdefinition[GO:0061085] silver  
1
  • Ortholog Compara
Regulation of histone H3-K4 methylationdefinition[GO:0051569] silver  
1
  • Ortholog Compara
Regulation of nephron tubule epithelial cell differentiationdefinition[GO:0072182]  
1
  • Ortholog Curator
Regulation of neuron apoptotic processdefinition[GO:0043523] silver  
1
  • Ortholog Compara
Regulation of neuron projection developmentdefinition[GO:0010975] silver  
1
  • Ortholog Compara
Response to drugdefinition[GO:0042493] silver  
1
  • Ortholog Compara
Response to estrogendefinition[GO:0043627]  
1
  • UniProtKB
Response to ethanoldefinition[GO:0045471] silver  
1
  • Ortholog Compara
Response to gamma radiationdefinition[GO:0010332] silver  
1
  • Ortholog Compara
Response to virusdefinition[GO:0009615]  
1
  • UniProtKB
Signal transductiondefinition[GO:0007165]  
1
  • Ortholog Curator
Sympathetic nervous system developmentdefinition[GO:0048485]  
1
  • Ortholog Curator
T cell receptor signaling pathwaydefinition[GO:0050852]  
1
  • Ortholog Curator
T-helper 2 cell differentiationdefinition[GO:0045064] silver  
1
  • Ortholog Compara
Thymic T cell selectiondefinition[GO:0045061] silver  
1
  • Ortholog Compara
Thymus developmentdefinition[GO:0048538] silver  
1
  • Ortholog Compara
TOR signalingdefinition[GO:0031929]  
1
  • Ortholog Curator
Transcription from RNA polymerase II promoterdefinition[GO:0006366]  
1
  • PINC
Type IV hypersensitivitydefinition[GO:0001806] silver  
1
  • Ortholog Compara
Ureter maturationdefinition[GO:0035799] silver  
1
  • Ortholog Compara
Ureteric bud formationdefinition[GO:0060676]  
1
  • Ortholog Curator
Uterus developmentdefinition[GO:0060065]  
1
  • Ortholog Curator
Ventricular septum developmentdefinition[GO:0003281]  
1
  • Ortholog Curator
Pathways 
According to Reactome, this protein belongs to the following pathway:
Factors involved in megakaryocyte development and platelet production  REACT_24970  
 

Keywords

Biological process 
Immunity  definition   [KW-0391]
Innate immunity  definition   [KW-0399]
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Activator  definition   [KW-0010]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: GATA3
GenomeRNAi: 2625
PRO: PR:P23771