FSHR - Follicle-stimulating hormone receptor - human protein (Function)
 
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FSHR »  Follicle-stimulating hormone receptor  (FSH-R)
 
Protein also known as:  Follitropin receptor.
Gene name:  FSHR
Entry whose protein(s) existence is based on evidence at protein level
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1 169 4
GENE REF ISO

Function

 show evidences
Overview 
Receptor for follicle-stimulating hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase.  
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the g-protein-coupled receptor (gpcr) family  9.A.14.1.5  
GO molecular function 
Follicle-stimulating hormone receptor activitydefinition[GO:0004963] silver  
  • IEAOrtholog Compara
Peptide hormone bindingdefinition[GO:0017046] silver  
  • IEAOrtholog Compara
Protein bindingdefinition[GO:0005515]  
3
  • IPIIntAct
  • IPIHGNC
GO biological process 
Adenylate cyclase-activating G-protein coupled receptor signaling pathwaydefinition[GO:0007189] silver  
  • IEAOrtholog Compara
Adenylate cyclase-inhibiting G-protein coupled receptor signaling pathwaydefinition[GO:0007193] silver  
  • IEAOrtholog Compara
Basement membrane organizationdefinition[GO:0071711] silver  
  • IEAOrtholog Compara
Cellular water homeostasisdefinition[GO:0009992] silver  
  • IEAOrtholog Compara
Female gamete generationdefinition[GO:0007292]  
1
  • TASPINC
Female gonad developmentdefinition[GO:0008585]  
1
  • TASPINC
G-protein coupled receptor signaling pathwaydefinition[GO:0007186]  
1
  • TASPINC
Gonad developmentdefinition[GO:0008406]  
1
  • TASPINC
Locomotory behaviordefinition[GO:0007626] silver  
  • IEAOrtholog Compara
Male gonad developmentdefinition[GO:0008584]  
1
  • IEPUniProtKB
Negative regulation of bone resorptiondefinition[GO:0045779] silver  
  • IEAOrtholog Compara
Neuron projection developmentdefinition[GO:0031175] silver  
  • IEAOrtholog Compara
Phospholipase C-activating G-protein coupled receptor signaling pathwaydefinition[GO:0007200] silver  
  • IEAOrtholog Compara
Positive regulation of intracellular estrogen receptor signaling pathwaydefinition[GO:0033148] silver  
  • IEAOrtholog Compara
Primary ovarian follicle growthdefinition[GO:0001545] silver  
  • IEAOrtholog Compara
Regulation of acetylcholine metabolic processdefinition[GO:0060408] silver  
  • IEAOrtholog Compara
Regulation of chromosome organizationdefinition[GO:0033044] silver  
  • IEAOrtholog Compara
Regulation of hormone metabolic processdefinition[GO:0032350] silver  
  • IEAOrtholog Compara
Regulation of MAPK cascadedefinition[GO:0043408] silver  
  • IEAOrtholog Compara
Regulation of osteoclast differentiationdefinition[GO:0045670] silver  
  • IEAOrtholog Compara
Regulation of platelet-derived growth factor receptor signaling pathwaydefinition[GO:0010640] silver  
  • IEAOrtholog Compara
Regulation of protein phosphorylationdefinition[GO:0001932] silver  
  • IEAOrtholog Compara
Regulation of systemic arterial blood pressuredefinition[GO:0003073] silver  
  • IEAOrtholog Compara
Sertoli cell developmentdefinition[GO:0060009] silver  
  • IEAOrtholog Compara
Sertoli cell proliferationdefinition[GO:0060011] silver  
  • IEAOrtholog Compara
Spermatogenesisdefinition[GO:0007283]  
1
  • TASPINC
Spermatogenesis, exchange of chromosomal proteinsdefinition[GO:0035093] silver  
  • IEAOrtholog Compara
Transcytosisdefinition[GO:0045056] silver  
  • IEAOrtholog Compara
Uterus developmentdefinition[GO:0060065] silver  
  • IEAOrtholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathway:
Neuroactive ligand-receptor interaction  hsa04080+2492  
According to Reactome, this protein belongs to the following pathway:
Signal Transduction  REACT_111102  
 

Keywords

Molecular function 
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Follicle-stimulating_hormone_receptor
GenomeRNAi: 2492
PRO: PR:P23945
Chemistry
GuidetoPHARMACOLOGY: 253