FSHR - Follicle-stimulating hormone receptor - human protein (Function)
 
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FSHR »  Follicle-stimulating hormone receptor  (FSH-R)
 
Protein also known as:  Follitropin receptor.
Gene name:  FSHR
Entry whose protein(s) existence is based on evidence at protein level
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1 184 4
GENE REF ISO

Function

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Overview 
Receptor for follicle-stimulating hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase.  
1
  • UniProtKB
According to TCDB this is a transporter from family:
the g-protein-coupled receptor (gpcr) family  9.A.14.1.5  
GO molecular function 
Follicle-stimulating hormone receptor activitydefinition[GO:0004963] silver  
1
  • InterPro 2 GO
G-protein coupled peptide receptor activitydefinition[GO:0008528]  
1
  • RefGenome
Protein bindingdefinition[GO:0005515]  
3
  • IntAct
  • HGNC
GO biological process 
Activation of adenylate cyclase activitydefinition[GO:0007190]  
1
  • RefGenome
Adenylate cyclase-activating G-protein coupled receptor signaling pathwaydefinition[GO:0007189]  
1
  • RefGenome
Female gamete generationdefinition[GO:0007292]  
1
  • PINC
Female gonad developmentdefinition[GO:0008585]  
1
  • PINC
Follicle-stimulating hormone signaling pathwaydefinition[GO:0042699]  
2
  • GOC
  • InterPro 2 GO
G-protein coupled receptor signaling pathwaydefinition[GO:0007186]  
1
  • PINC
Gonad developmentdefinition[GO:0008406]  
1
  • PINC
Hormone-mediated signaling pathwaydefinition[GO:0009755]  
1
  • RefGenome
Male gonad developmentdefinition[GO:0008584]  
1
  • UniProtKB
Primary ovarian follicle growthdefinition[GO:0001545]  
1
  • RefGenome
Regulation of osteoclast differentiationdefinition[GO:0045670]  
1
  • RefGenome
Spermatogenesisdefinition[GO:0007283]  
1
  • PINC
Uterus developmentdefinition[GO:0060065]  
1
  • RefGenome
Pathways 
According to KEGG, this protein belongs to the following pathway:
Neuroactive ligand-receptor interaction  hsa04080+2492  
According to Reactome, this protein belongs to the following pathways:
G alpha (s) signalling events  REACT_19327  
Hormone ligand-binding receptors  REACT_16942  
 

Keywords

Molecular function 
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Follicle-stimulating_hormone_receptor
GenomeRNAi: 2492
PRO: PR:P23945
Chemistry
GuidetoPHARMACOLOGY: 253