CMA1 - Chymase - human protein (Function)
 
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CMA1 »  Chymase   [ EC 3.4.21.39 ]
 
Protein also known as:  Mast cell protease I.
Gene name:  CMA1
Family name: Peptidase S1 » Granzyme
Entry whose protein(s) existence is based on evidence at protein level
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1 77 1
GENE REF ISO

Function

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Overview 
Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion.  
  • CuratedUniProtKB
GO molecular function 
Peptide bindingdefinition[GO:0042277] silver  
  • IEAOrtholog Compara
Serine-type endopeptidase activitydefinition[GO:0004252]  
2
  • NASUniProtKB
  • IDABHF-UCL
Serine-type peptidase activitydefinition[GO:0008236]  
1
  • TASPINC
GO biological process 
Cellular response to glucose stimulusdefinition[GO:0071333] silver  
  • IEAOrtholog Compara
Interleukin-1 beta biosynthetic processdefinition[GO:0050720]  
1
  • IDABHF-UCL
Midbrain developmentdefinition[GO:0030901] silver  
  • IEAOrtholog Compara
Peptide metabolic processdefinition[GO:0006518] silver  
  • IEAOrtholog Compara
Positive regulation of angiogenesisdefinition[GO:0045766] silver  
  • IEAOrtholog Compara
Proteolysisdefinition[GO:0006508] silver  
  • IBARefGenome
Regulation of inflammatory responsedefinition[GO:0050727]  
1
  • ICBHF-UCL
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.4.21.39: Preferential cleavage: Phe-|-Xaa > Tyr-|-Xaa > Trp-|-Xaa > Leu-|-Xaa.  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathway:
Renin-angiotensin system  hsa04614+1215  
According to Reactome, this protein belongs to the following pathways:
Activation of Matrix Metalloproteinases  REACT_118682  
Metabolism of Angiotensinogen to Angiotensins  REACT_147707  
Signaling by SCF-KIT  REACT_111040  
 

Keywords

Molecular function 
Hydrolase  definition   [KW-0378]
Protease  definition   [KW-0645]
Serine protease  definition   [KW-0720]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: P23946
Other
GeneWiki: CMA1
GenomeRNAi: 1215
PRO: PR:P23946
Chemistry
GuidetoPHARMACOLOGY: 2340