LAMA2 - Laminin subunit alpha-2 - human protein (Function)
 
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LAMA2 »  Laminin subunit alpha-2
 
Protein also known as:  Laminin-12 subunit alpha.
Gene name:  LAMA2
Entry whose protein(s) existence is based on evidence at protein level
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1 68 1
GENE REF ISO

Function

 show evidences
Overview 
Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.  
  • CuratedUniProtKB
GO molecular function 
Receptor bindingdefinition[GO:0005102] silver  
  • IEAInterPro 2 GO
Structural molecule activitydefinition[GO:0005198]  
1
  • TASPINC
GO biological process 
Axon guidancedefinition[GO:0007411] silver  
  • IEAOrtholog Compara
Cell adhesiondefinition[GO:0007155]  
  • IEAUniProtKB KW
Muscle organ developmentdefinition[GO:0007517]  
1
  • TASPINC
Myelination in peripheral nervous systemdefinition[GO:0022011] silver  
  • IEAOrtholog Compara
Positive regulation of synaptic transmission, cholinergicdefinition[GO:0032224] silver  
  • IEAOrtholog Compara
Regulation of cell adhesiondefinition[GO:0030155] silver  
  • IEAInterPro 2 GO
Regulation of cell migrationdefinition[GO:0030334] silver  
  • IEAInterPro 2 GO
Regulation of embryonic developmentdefinition[GO:0045995] silver  
  • IEAInterPro 2 GO
Pathways 
According to KEGG, this protein belongs to the following pathways:
Amoebiasis  hsa05146+3908  
Arrhythmogenic right ventricular cardiomyopathy (ARVC)  hsa05412+3908  
Dilated cardiomyopathy  hsa05414+3908  
ECM-receptor interaction  hsa04512+3908  
Focal adhesion  hsa04510+3908  
Hypertrophic cardiomyopathy (HCM)  hsa05410+3908  
Pathways in cancer  hsa05200+3908  
Small cell lung cancer  hsa05222+3908  
Toxoplasmosis  hsa05145+3908  
Viral myocarditis  hsa05416+3908  
According to Reactome, this protein belongs to the following pathway:
Extracellular matrix organization  REACT_118779  
 

Keywords

Biological process 
Cell adhesion  definition   [KW-0130]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Laminin,_alpha_2
GenomeRNAi: 3908
PRO: PR:P24043