PRTN3 - Myeloblastin - human protein (Function)
 
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PRTN3 »  Myeloblastin   [ EC 3.4.21.76 ]
 
Protein also known as:  Neutrophil proteinase 4 (NP-4).
Gene name:  PRTN3
Family name: Peptidase S1 » Elastase
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Polymorphonuclear leukocyte serine protease that degrades elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV (in vitro) and causes emphysema when administered by tracheal insufflation to hamsters.  
1
  • UniProtKB
GO molecular function 
Enzyme bindingdefinition[GO:0019899]  
1
  • UniProtKB
Serine-type endopeptidase activitydefinition[GO:0004252] silver  
1
  • InterPro 2 GO
Serine-type peptidase activitydefinition[GO:0008236]  
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  • PINC
GO biological process 
Collagen catabolic processdefinition[GO:0030574]  
1
  • UniProtKB KW
Mature conventional dendritic cell differentiationdefinition[GO:0097029]  
1
  • UniProtKB
Negative regulation of phagocytosisdefinition[GO:0050765]  
1
  • UniProtKB
Positive regulation of cell proliferationdefinition[GO:0008284]  
1
  • PINC
Proteolysisdefinition[GO:0006508]  
1
  • UniProtKB KW
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.4.21.76: Hydrolysis of proteins, including elastin, by preferential cleavage: -Ala-|-Xaa- > -Val-|-Xaa-.  
2
  • UniProtKB
 
More information is available from:
 

Keywords

Biological process 
Collagen degradation  definition   [KW-0177]
Molecular function 
Hydrolase  definition   [KW-0378]
Protease  definition   [KW-0645]
Serine protease  definition   [KW-0720]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Proteinase_3
GenomeRNAi: 5657
PRO: PR:P24158