MMP11 - Stromelysin-3 - human protein (Function)
 
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Protein
Gene
References

 
MMP11 »  Stromelysin-3
 
Gene name:  MMP11
Family name: Peptidase M10A
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
May play an important role in the progression of epithelial malignancies.  
  • CuratedUniProtKB
GO molecular function 
Calcium ion bindingdefinition[GO:0005509] silver  
  • IEAInterPro 2 GO
Metalloendopeptidase activitydefinition[GO:0004222] silver  
  • IEAInterPro 2 GO
Zinc ion bindingdefinition[GO:0008270] silver  
  • IEAInterPro 2 GO
GO biological process 
Basement membrane organizationdefinition[GO:0071711] silver  
  • IEAOrtholog Compara
Collagen fibril organizationdefinition[GO:0030199] silver  
  • IEAOrtholog Compara
Multicellular organismal developmentdefinition[GO:0007275] silver  
  • IEAInterPro 2 GO
Negative regulation of fat cell differentiationdefinition[GO:0045599] silver  
  • IEAOrtholog Compara
Proteolysisdefinition[GO:0006508]  
  • IEAUniProtKB KW
Enzymatic activity 
It requires the following cofactors
Binds 1 calcium ion per subunit (By similarity).  
  • CuratedUniProtKB
Binds 2 zinc ions per subunit (By similarity).  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to Reactome, this protein belongs to the following pathways:
Activation of Matrix Metalloproteinases  REACT_118682  
Collagen degradation  REACT_150401  
Degradation of the extracellular matrix  REACT_118572  
 

Keywords

Biological process 
Collagen degradation  definition   [KW-0177]
Molecular function 
Hydrolase  definition   [KW-0378]
Metalloprotease  definition   [KW-0482]
Protease  definition   [KW-0645]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: MMP11
GenomeRNAi: 4320
PRO: PR:P24347