MMP11 - Stromelysin-3 - human protein (Function)
 
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MMP11 »  Stromelysin-3   [ EC 3.4.24.- ]  (ST3)
 
Protein also known as:  Matrix metalloproteinase-11 (MMP-11).
Gene name:  MMP11
Family name: Peptidase M10A
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

 show evidences
Overview 
May play an important role in the progression of epithelial malignancies.  
  • CuratedUniProtKB
GO molecular function 
Calcium ion bindingdefinition[GO:0005509] silver  
  • IEAInterPro 2 GO
Metalloendopeptidase activitydefinition[GO:0004222] silver  
  • IEAInterPro 2 GO
Zinc ion bindingdefinition[GO:0008270] silver  
  • IEAInterPro 2 GO
GO biological process 
Basement membrane organizationdefinition[GO:0071711] silver  
  • IEAOrtholog Compara
Collagen fibril organizationdefinition[GO:0030199] silver  
  • IEAOrtholog Compara
Multicellular organismal developmentdefinition[GO:0007275] silver  
  • IEAInterPro 2 GO
Negative regulation of fat cell differentiationdefinition[GO:0045599] silver  
  • IEAOrtholog Compara
Proteolysisdefinition[GO:0006508]  
1
  • TASPINC
Enzymatic activity 
It requires the following cofactors
Binds 1 calcium ion per subunit (By similarity).  
  • CuratedUniProtKB
Binds 2 zinc ions per subunit (By similarity).  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to Reactome, this protein belongs to the following pathway:
Extracellular matrix organization  REACT_118779  
 

Keywords

Biological process 
Collagen degradation  definition   [KW-0177]
Molecular function 
Hydrolase  definition   [KW-0378]
Metalloprotease  definition   [KW-0482]
Protease  definition   [KW-0645]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: MMP11
GenomeRNAi: 4320
PRO: PR:P24347