CCND1 - G1/S-specific cyclin-D1 - human protein (Function)
 
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Protein
Gene
References

 
CCND1 »  G1/S-specific cyclin-D1
 
Protein also known as:  B-cell lymphoma 1 protein (BCL-1).
Gene name:  CCND1
Family name: Cyclin » Cyclin D
Entry whose protein(s) existence is based on evidence at protein level
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1 822 1
GENE REF ISO

Function

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Overview 
Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D1/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. Exhibits transcriptional corepressor activity with INSM1 on the NEUROD1 and INS promoters in a cell cycle-independent manner.  
4
  • CuratedUniProtKB
GO molecular function 
Cyclin-dependent protein serine/threonine kinase regulator activitydefinition[GO:0016538] silver  
  • IEAOrtholog Compara
Enzyme bindingdefinition[GO:0019899]  
1
  • IPIUniProtKB
Histone deacetylase bindingdefinition[GO:0042826]  
1
  • IPIUniProtKB
Proline-rich region bindingdefinition[GO:0070064]  
1
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
13
  • IPIIntAct
  • IPIUniProtKB
Protein complex bindingdefinition[GO:0032403] silver  
  • IEAOrtholog Compara
Protein kinase activitydefinition[GO:0004672] silver  
  • IEAOrtholog Compara
Protein kinase bindingdefinition[GO:0019901]  
2
  • IPIUniProtKB
  • IPIBHF-UCL
Transcription corepressor activitydefinition[GO:0003714]  
2
  • IDAUniProtKB
Transcription factor bindingdefinition[GO:0008134]  
2
  • IPIUniProtKB
GO biological process 
Canonical Wnt signaling pathwaydefinition[GO:0060070] silver  
  • IEAOrtholog Compara
Cell divisiondefinition[GO:0051301]  
  • IEAUniProtKB KW
Cellular response to DNA damage stimulusdefinition[GO:0006974]  
1
  • IDAUniProtKB
Endoplasmic reticulum unfolded protein responsedefinition[GO:0030968] silver  
  • IEAOrtholog Compara
Fat cell differentiationdefinition[GO:0045444] silver  
  • IEAOrtholog Compara
G1/S transition of mitotic cell cycledefinition[GO:0000082]  
2
  • IDAUniProtKB
  • TASBHF-UCL
Lactationdefinition[GO:0007595] silver  
  • IEAOrtholog Compara
Leydig cell differentiationdefinition[GO:0033327] silver  
  • IEAOrtholog Compara
Liver developmentdefinition[GO:0001889] silver  
  • IEAOrtholog Compara
Mammary gland alveolus developmentdefinition[GO:0060749] silver  
  • IEAOrtholog Compara
Mammary gland epithelial cell proliferationdefinition[GO:0033598] silver  
  • IEAOrtholog Compara
Mitotic G1 DNA damage checkpointdefinition[GO:0031571]  
1
  • IDAUniProtKB
Negative regulation of cell cycle arrestdefinition[GO:0071157]  
1
  • IDAUniProtKB
Negative regulation of epithelial cell differentiationdefinition[GO:0030857] silver  
  • IEAOrtholog Compara
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122]  
2
  • IDAUniProtKB
Negative regulation of Wnt signaling pathwaydefinition[GO:0030178] silver  
  • IEAOrtholog Compara
Organ regenerationdefinition[GO:0031100] silver  
  • IEAOrtholog Compara
Positive regulation of cyclin-dependent protein serine/threonine kinase activitydefinition[GO:0045737]  
1
  • IDABHF-UCL
Positive regulation of G2/M transition of mitotic cell cycledefinition[GO:0010971]  
1
  • IDAUniProtKB
Positive regulation of mammary gland epithelial cell proliferationdefinition[GO:0033601] silver  
  • IEAOrtholog Compara
Positive regulation of protein phosphorylationdefinition[GO:0001934]  
1
  • IDABHF-UCL
Protein phosphorylationdefinition[GO:0006468] silver  
  • IEAOrtholog Compara
Re-entry into mitotic cell cycledefinition[GO:0000320] silver  
  • IEAOrtholog Compara
Response to calcium iondefinition[GO:0051592] silver  
  • IEAOrtholog Compara
Response to corticosteronedefinition[GO:0051412] silver  
  • IEAOrtholog Compara
Response to drugdefinition[GO:0042493]  
1
  • IEPUniProtKB
Response to estrogendefinition[GO:0043627] silver  
  • IEAOrtholog Compara
Response to ethanoldefinition[GO:0045471] silver  
  • IEAOrtholog Compara
Response to iron iondefinition[GO:0010039] silver  
  • IEAOrtholog Compara
Response to magnesium iondefinition[GO:0032026] silver  
  • IEAOrtholog Compara
Response to organonitrogen compounddefinition[GO:0010243] silver  
  • IEAOrtholog Compara
Response to UV-Adefinition[GO:0070141]  
1
  • IDABHF-UCL
Response to vitamin Edefinition[GO:0033197] silver  
  • IEAOrtholog Compara
Response to X-raydefinition[GO:0010165] silver  
  • IEAOrtholog Compara
Transcription, DNA-templateddefinition[GO:0006351]  
  • IEAUniProtKB KW
Pathways 
According to KEGG, this protein belongs to the following pathways:
Acute myeloid leukemia  hsa05221+595  
Bladder cancer  hsa05219+595  
Cell cycle  hsa04110+595  
Chronic myeloid leukemia  hsa05220+595  
Colorectal cancer  hsa05210+595  
Endometrial cancer  hsa05213+595  
Focal adhesion  hsa04510+595  
Glioma  hsa05214+595  
HTLV-I infection  hsa05166+595  
Jak-STAT signaling pathway  hsa04630+595  
Measles  hsa05162+595  
Melanoma  hsa05218+595  
Non-small cell lung cancer  hsa05223+595  
p53 signaling pathway  hsa04115+595  
Pancreatic cancer  hsa05212+595  
Pathways in cancer  hsa05200+595  
Prostate cancer  hsa05215+595  
Small cell lung cancer  hsa05222+595  
Thyroid cancer  hsa05216+595  
Viral myocarditis  hsa05416+595  
Wnt signaling pathway  hsa04310+595  
According to Reactome, this protein belongs to the following pathways:
Cyclin D associated events in G1  REACT_821  
Pre-NOTCH Transcription and Translation  REACT_118568  
Ubiquitin-dependent degradation of Cyclin D1  REACT_4  
 

Keywords

Biological process 
Cell cycle  definition   [KW-0131]
Cell division  definition   [KW-0132]
DNA damage  definition   [KW-0227]
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Cyclin  definition   [KW-0195]
Repressor  definition   [KW-0678]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Cyclin_D1
GenomeRNAi: 595
PRO: PR:P24385