CHM - Rab proteins geranylgeranyltransferase component A 1 - human protein (Function)
 
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CHM »  Rab proteins geranylgeranyltransferase component A 1
 
Protein also known as:  Choroideremia protein.
Gene name:  CHM
Family name: Rab GDI
Entry whose protein(s) existence is based on evidence at protein level
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1 28 2
GENE REF ISO

Function

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Overview 
Substrate-binding subunit of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B composed of RABGGTA and RABGGTB, and remains bound to it after the geranylgeranyl transfer reaction. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. Besides, a pre-formed complex consisting of CHM and the Rab GGTase dimer (RGGT or component B) can bind to and prenylate Rab proteins; this alternative pathway is proposed to be the predominant pathway for Rab protein geranylgeranylation.  
2
  • CuratedUniProtKB
GO molecular function 
GTPase activator activitydefinition[GO:0005096]  
  • IEAUniProtKB KW
Rab geranylgeranyltransferase activitydefinition[GO:0004663] silver  
  • IEAInterPro 2 GO
Rab GTPase bindingdefinition[GO:0017137]  
2
  • IDAUniProtKB
GO biological process 
Blood vessel developmentdefinition[GO:0001568] silver  
  • IEAOrtholog Compara
Positive regulation of GTPase activitydefinition[GO:0043547]  
  • IEAUniProtKB KW
Protein geranylgeranylationdefinition[GO:0018344]  
1
  • IDAUniProtKB
Protein targeting to membranedefinition[GO:0006612]  
1
  • IMPUniProtKB
Response to stimulusdefinition[GO:0050896]  
  • IEAUniProtKB KW
Visual perceptiondefinition[GO:0007601]  
  • IEAUniProtKB KW
 

Keywords

Biological process 
Sensory transduction  definition   [KW-0716]
Vision  definition   [KW-0844]
Molecular function 
GTPase activation  definition   [KW-0343]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Rab_escort_protein
GenomeRNAi: 1121
PRO: PR:P24386