NR2F2 - COUP transcription factor 2 - human protein (Function)
 
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NR2F2 »  COUP transcription factor 2  (COUP-TF2)
 
Protein also known as:  Nuclear receptor subfamily 2 group F member 2.
Gene name:  NR2F2
Family name: Nuclear hormone receptor » NR2
Entry whose protein(s) existence is based on evidence at protein level
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1 53 3
GENE REF ISO

Function

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Overview 
Ligand-activated transcription factor. Activated by high concentrations of 9-cis-retinoic acid and all-trans-retinoic acid, but not by dexamethasone, cortisol or progesterone (in vitro). Regulation of the apolipoprotein A-I gene transcription. Binds to DNA site A.  
3
  • CuratedUniProtKB
GO molecular function 
Ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activitydefinition[GO:0004879]  
1
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
3
  • IPIBHF-UCL
  • IPIUniProtKB
Protein homodimerization activitydefinition[GO:0042803]  
1
  • IPIUniProtKB
Retinoic acid bindingdefinition[GO:0001972]  
1
  • IDAUniProtKB
Sequence-specific DNA bindingdefinition[GO:0043565]  
1
  • IDAUniProtKB
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700]  
2
  • ICBHF-UCL
  • IDAUniProtKB
Steroid hormone receptor activitydefinition[GO:0003707] silver  
  • IEAInterPro 2 GO
Transcription corepressor activitydefinition[GO:0003714]  
1
  • TASPINC
Zinc ion bindingdefinition[GO:0008270] silver  
  • IEAInterPro 2 GO
GO biological process 
Anterior/posterior pattern specificationdefinition[GO:0009952] silver  
  • IEAOrtholog Compara
Blood vessel morphogenesisdefinition[GO:0048514] silver  
  • IEAOrtholog Compara
Fertilizationdefinition[GO:0009566] silver  
  • IEAOrtholog Compara
Forebrain developmentdefinition[GO:0030900] silver  
  • IEAOrtholog Compara
Intracellular receptor signaling pathwaydefinition[GO:0030522]  
2
  • IDAGOC
Limb developmentdefinition[GO:0060173] silver  
  • IEAOrtholog Compara
Lipid metabolic processdefinition[GO:0006629]  
1
  • TASPINC
Maternal placenta developmentdefinition[GO:0001893] silver  
  • IEAOrtholog Compara
Negative regulation of cyclin-dependent protein serine/threonine kinase activitydefinition[GO:0045736]  
1
  • IDABHF-UCL
Negative regulation of endothelial cell migrationdefinition[GO:0010596]  
1
  • IMPBHF-UCL
Negative regulation of endothelial cell proliferationdefinition[GO:0001937]  
1
  • IMPBHF-UCL
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122]  
1
  • IDAUniProtKB
Negative regulation of transcription, DNA-templateddefinition[GO:0045892]  
1
  • IDABHF-UCL
Neuron migrationdefinition[GO:0001764] silver  
  • IEAOrtholog Compara
Placenta blood vessel developmentdefinition[GO:0060674] silver  
  • IEAOrtholog Compara
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
2
  • IMPBHF-UCL
  • IDAUniProtKB
Radial pattern formationdefinition[GO:0009956] silver  
  • IEAOrtholog Compara
Regulation of transcription from RNA polymerase II promoterdefinition[GO:0006357]  
1
  • TASPINC
Regulation of transcription involved in lymphatic endothelial cell fate commitmentdefinition[GO:0060849]  
1
  • IMPBHF-UCL
Response to estradioldefinition[GO:0032355] silver  
  • IEAOrtholog Compara
Signal transductiondefinition[GO:0007165]  
1
  • TASPINC
Skeletal muscle tissue developmentdefinition[GO:0007519] silver  
  • IEAOrtholog Compara
Trophoblast giant cell differentiationdefinition[GO:0060707] silver  
  • IEAOrtholog Compara
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Activator  definition   [KW-0010]
Receptor  definition   [KW-0675]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: COUP-TFII
GenomeRNAi: 7026
PRO: PR:P24468