EDNRB - Endothelin B receptor - human protein (Function)
 
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EDNRB »  Endothelin B receptor  (ET-B)
 
Protein also known as:  Endothelin receptor non-selective type.
Gene name:  EDNRB
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.  
1
  • CuratedUniProtKB
GO molecular function 
Endothelin receptor activitydefinition[GO:0004962]  
2
  • IMPBHF-UCL
Peptide hormone bindingdefinition[GO:0017046]  
1
  • IPIBHF-UCL
Protein bindingdefinition[GO:0005515]  
1
  • IPIIntAct
Type 1 angiotensin receptor bindingdefinition[GO:0031702] silver  
  • IEAOrtholog Compara
GO biological process 
Agingdefinition[GO:0007568] silver  
  • IEAOrtholog Compara
Cell surface receptor signaling pathwaydefinition[GO:0007166]  
1
  • TASPINC
Cellular response to lipopolysaccharidedefinition[GO:0071222] silver  
  • IEAOrtholog Compara
cGMP-mediated signalingdefinition[GO:0019934] silver  
  • IEAOrtholog Compara
Endothelin receptor signaling pathwaydefinition[GO:0086100]  
2
  • IMPGOC
  • IEAOrtholog Compara
  • IEAInterPro 2 GO
Enteric nervous system developmentdefinition[GO:0048484]  
  • ISSOrtholog Curator
Enteric smooth muscle cell differentiationdefinition[GO:0035645]  
  • ISSOrtholog Curator
Epithelial fluid transportdefinition[GO:0042045] silver  
  • IEAOrtholog Compara
Macrophage chemotaxisdefinition[GO:0048246]  
1
  • IMPBHF-UCL
Melanocyte differentiationdefinition[GO:0030318] silver  
  • IEAOrtholog Compara
Negative regulation of adenylate cyclase activitydefinition[GO:0007194]  
1
  • TASPINC
Negative regulation of apoptotic processdefinition[GO:0043066] silver  
  • IEAOrtholog Compara
Negative regulation of cellular protein metabolic processdefinition[GO:0032269]  
1
  • IMPBHF-UCL
Negative regulation of neuron maturationdefinition[GO:0014043]  
  • ISSOrtholog Curator
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122]  
1
  • IMPBHF-UCL
  • ISSOrtholog Curator
Nervous system developmentdefinition[GO:0007399]  
1
  • TASPINC
Neural crest cell migrationdefinition[GO:0001755] silver  
  • IEAOrtholog Compara
Peripheral nervous system developmentdefinition[GO:0007422] silver  
  • IEAOrtholog Compara
Phospholipase C-activating G-protein coupled receptor signaling pathwaydefinition[GO:0007200] silver  
  • IEAOrtholog Compara
Positive regulation of cell proliferationdefinition[GO:0008284] silver  
  • IEAOrtholog Compara
Positive regulation of cytosolic calcium ion concentrationdefinition[GO:0007204] silver  
  • IEAOrtholog Compara
Positive regulation of penile erectiondefinition[GO:0060406] silver  
  • IEAOrtholog Compara
Positive regulation of protein phosphorylationdefinition[GO:0001934] silver  
  • IEAOrtholog Compara
Positive regulation of renal sodium excretiondefinition[GO:0035815] silver  
  • IEAOrtholog Compara
Positive regulation of urine volumedefinition[GO:0035810] silver  
  • IEAOrtholog Compara
Posterior midgut developmentdefinition[GO:0007497] silver  
  • IEAOrtholog Compara
Regulation of blood pressuredefinition[GO:0008217] silver  
  • IEAOrtholog Compara
Regulation of epithelial cell proliferationdefinition[GO:0050678] silver  
  • IEAOrtholog Compara
Regulation of fever generationdefinition[GO:0031620] silver  
  • IEAOrtholog Compara
Regulation of pHdefinition[GO:0006885] silver  
  • IEAOrtholog Compara
Regulation of sensory perception of paindefinition[GO:0051930] silver  
  • IEAOrtholog Compara
Response to organic cyclic compounddefinition[GO:0014070] silver  
  • IEAOrtholog Compara
Response to paindefinition[GO:0048265] silver  
  • IEAOrtholog Compara
Sensory perception of paindefinition[GO:0019233] silver  
  • IEAOrtholog Compara
Vasoconstrictiondefinition[GO:0042310]  
1
  • IMPBHF-UCL
Vasodilationdefinition[GO:0042311] silver  
  • IEAOrtholog Compara
Vein smooth muscle contractiondefinition[GO:0014826]  
1
  • IMPBHF-UCL
Pathways 
According to KEGG, this protein belongs to the following pathways:
Calcium signaling pathway  hsa04020+1910  
Melanogenesis  hsa04916+1910  
Neuroactive ligand-receptor interaction  hsa04080+1910  
According to Reactome, this protein belongs to the following pathways:
G alpha (q) signalling events  REACT_18283  
Peptide ligand-binding receptors  REACT_14819  
 

Keywords

Molecular function 
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Endothelin_receptor_type_B
GenomeRNAi: 1910
PRO: PR:P24530
Chemistry
GuidetoPHARMACOLOGY: 220