TBXAS1 - Thromboxane-A synthase - human protein (Function)
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TBXAS1 »  Thromboxane-A synthase   [ EC ]  (TXS)
Protein also known as:  Cytochrome P450 5A1.
Gene name:  TBXAS1
Family name: Cytochrome P450
Entry whose protein(s) existence is based on evidence at protein level
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GO molecular function 
Heme bindingdefinition[GO:0020037] silver  
  • IEAInterPro 2 GO
Iron ion bindingdefinition[GO:0005506] silver  
  • IEAInterPro 2 GO
Monooxygenase activitydefinition[GO:0004497]  
  • IEAUniProtKB KW
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygendefinition[GO:0016705] silver  
  • IEAInterPro 2 GO
Thromboxane-A synthase activitydefinition[GO:0004796]  
  • IEAEC 2 GO
GO biological process 
Oxidation-reduction processdefinition[GO:0055114]  
  • IEAUniProtKB KW
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC (5Z,13E)-(15S)-9-alpha,11-alpha-epidioxy-15-hydroxyprosta-5,13-dienoate (5Z,13E)-(15S)-9-alpha,11-alpha-epoxy-15-hydroxythromboxa-5,13-dienoate.  
  • CuratedUniProtKB
It requires the following cofactor
Heme group.  
  • CuratedUniProtKB
According to KEGG, this protein belongs to the following pathways:
Arachidonic acid metabolism  hsa00590+6916  
Metabolic pathways  hsa01100+6916  
According to Reactome, this protein belongs to the following pathways:
Eicosanoids  REACT_13645  
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)  REACT_150149  
More information is available from:


Biological process 
Fatty acid biosynthesis  definition   [KW-0275]
Fatty acid metabolism  definition   [KW-0276]
Lipid biosynthesis  definition   [KW-0444]
Lipid metabolism  definition   [KW-0443]
Prostaglandin biosynthesis  definition   [KW-0643]
Prostaglandin metabolism  definition   [KW-0644]
Molecular function 
Isomerase  definition   [KW-0413]
Monooxygenase  definition   [KW-0503]
Oxidoreductase  definition   [KW-0560]
Technical term 
Reference proteome  definition   [KW-1185]

Further external links

GeneWiki: Thromboxane-A_synthase
GenomeRNAi: 6916
PRO: PR:P24557