IGFBP6 - Insulin-like growth factor-binding protein 6 - human protein (Function)
 
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Protein
Gene
References

 
IGFBP6 »  Insulin-like growth factor-binding protein 6  (IBP-6)
 
Gene name:  IGFBP6
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.  
  • CuratedUniProtKB
GO molecular function 
Insulin-like growth factor I bindingdefinition[GO:0031994] silver  
  • IEAOrtholog Compara
GO biological process 
Negative regulation of cell proliferationdefinition[GO:0008285]  
1
  • TASPINC
Regulation of cell growthdefinition[GO:0001558] silver  
  • IEAInterPro 2 GO
Signal transductiondefinition[GO:0007165]  
1
  • NASPINC
Pathways 
According to Reactome, this protein belongs to the following pathway:
Metabolism of proteins  REACT_17015  
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: IGFBP6
GenomeRNAi: 3489
PRO: PR:P24592