IGFBP6 - Insulin-like growth factor-binding protein 6 - human protein (Function)
 
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IGFBP6 »  Insulin-like growth factor-binding protein 6  (IBP-6)
 
Gene name:  IGFBP6
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.  
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  • UniProtKB
GO molecular function 
Insulin-like growth factor I bindingdefinition[GO:0031994]  
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  • RefGenome
Insulin-like growth factor II bindingdefinition[GO:0031995]  
1
  • RefGenome
GO biological process 
Negative regulation of cell proliferationdefinition[GO:0008285]  
1
  • PINC
Regulation of cell growthdefinition[GO:0001558] silver  
1
  • InterPro 2 GO
Regulation of insulin-like growth factor receptor signaling pathwaydefinition[GO:0043567]  
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  • RefGenome
Signal transductiondefinition[GO:0007165]  
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  • PINC
Enzymatic activity 
 
More information is available from:
Pathways 
According to Reactome, this protein belongs to the following pathway:
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)  REACT_15428  
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: IGFBP6
GenomeRNAi: 3489
PRO: PR:P24592