ACP1 - Low molecular weight phosphotyrosine protein phosphatase - human protein (Function)
 
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ACP1 »  Low molecular weight phosphotyrosine protein phosphatase   [ EC 3.1.3.48 ]  (LMW-PTP)
 
Protein also known as:  Low molecular weight cytosolic acid phosphatase [EC 3.1.3.2].
Gene name:  ACP1
Entry whose protein(s) existence is based on evidence at protein level
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1 36 4
GENE REF ISO

Function

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Overview 
Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates.  
  • CuratedUniProtKB
Isoform  Iso 3   Does not possess phosphatase activity.  
  • CuratedUniProtKB
GO molecular function 
Acid phosphatase activitydefinition[GO:0003993]  
  • IEAEC 2 GO
Non-membrane spanning protein tyrosine phosphatase activitydefinition[GO:0004726] silver  
  • IEAInterPro 2 GO
Protein bindingdefinition[GO:0005515]  
1
  • IPIUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reactions
EC 3.1.3.48: Protein tyrosine phosphate + H(2)O protein tyrosine + phosphate.  
  • CuratedUniProtKB
EC 3.1.3.2: A phosphate monoester + H(2)O an alcohol + phosphate.  
  • CuratedUniProtKB
It is regulated in the following manner
Inhibited by sulfhydryl reagents.  
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Adherens junction  hsa04520+52  
Riboflavin metabolism  hsa00740+52  
 

Keywords

Molecular function 
Hydrolase  definition   [KW-0378]
Protein phosphatase  definition   [KW-0904]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ACP1
GenomeRNAi: 52
PRO: PR:P24666