ACAT1 - Acetyl-CoA acetyltransferase, mitochondrial - human protein (Function)
 
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Protein
Gene
References

 
ACAT1 »  Acetyl-CoA acetyltransferase, mitochondrial   [ EC 2.3.1.9 ]
 
Protein also known as:  Acetoacetyl-CoA thiolase.
Gene name:  ACAT1
Family name: Thiolase
Entry whose protein(s) existence is based on evidence at protein level
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1 48 1
GENE REF ISO

Function

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Overview 
Plays a major role in ketone body metabolism.  
  • CuratedUniProtKB
GO molecular function 
Coenzyme bindingdefinition[GO:0050662] silver  
  • IEAOrtholog Compara
Enzyme bindingdefinition[GO:0019899] silver  
  • IEAOrtholog Compara
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
Protein homodimerization activitydefinition[GO:0042803] silver  
  • IEAOrtholog Compara
GO biological process 
Adipose tissue developmentdefinition[GO:0060612] silver  
  • IEAOrtholog Compara
Brain developmentdefinition[GO:0007420] silver  
  • IEAOrtholog Compara
Liver developmentdefinition[GO:0001889] silver  
  • IEAOrtholog Compara
Metanephric proximal convoluted tubule developmentdefinition[GO:0072229] silver  
  • IEAOrtholog Compara
Protein homooligomerizationdefinition[GO:0051260] silver  
  • IEAOrtholog Compara
Response to hormonedefinition[GO:0009725] silver  
  • IEAOrtholog Compara
Response to organic cyclic compounddefinition[GO:0014070] silver  
  • IEAOrtholog Compara
Response to starvationdefinition[GO:0042594] silver  
  • IEAOrtholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.3.1.9: 2 acetyl-CoA CoA + acetoacetyl-CoA.  
1
  • CuratedUniProtKB
It is regulated in the following manner
Activated by potassium ions, but not sodium ions.  
1
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Butanoate metabolism  hsa00650+38  
Fatty acid metabolism  hsa00071+38  
Glyoxylate and dicarboxylate metabolism  hsa00630+38  
Lysine degradation  hsa00310+38  
Metabolic pathways  hsa01100+38  
Propanoate metabolism  hsa00640+38  
Pyruvate metabolism  hsa00620+38  
Synthesis and degradation of ketone bodies  hsa00072+38  
Terpenoid backbone biosynthesis  hsa00900+38  
Tryptophan metabolism  hsa00380+38  
Valine, leucine and isoleucine degradation  hsa00280+38  
According to Reactome, this protein belongs to the following pathway:
Metabolism  REACT_111217  
 
More information is available from:
 

Biophysicochemical properties

Kinetic parameters
KM 8 uM for 2-methylacetoacetyl coenzyme A
KM 20 uM for coenzyme A
KM 4 uM for acetoacetyl coenzyme A
KM 508 uM for acetyl coenzyme A

Keywords

Molecular function 
Acyltransferase  definition   [KW-0012]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ACAT1
GenomeRNAi: 38
PRO: PR:P24752