CXCR1 - C-X-C chemokine receptor type 1 - human protein (Function)
 
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Protein
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References

 
CXCR1 »  C-X-C chemokine receptor type 1  (CXCR-1)
 
Protein also known as:  High affinity interleukin-8 receptor A (IL-8R A); CD antigen CD181.
Gene name:  CXCR1
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 116 1
GENE REF ISO

Function

 show evidences
Overview 
Receptor to interleukin-8, which is a powerful neutrophils chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activate a phosphatidylinositol-calcium second messenger system. This receptor binds to IL-8 with a high affinity and to MGSA (GRO) with a low affinity.  
  • CuratedUniProtKB
GO molecular function 
Chemokine receptor activitydefinition[GO:0004950]  
1
  • TASPINC
G-protein coupled receptor activitydefinition[GO:0004930]  
1
  • TASPINC
Interleukin-8 bindingdefinition[GO:0019959]  
1
  • IPIUniProtKB
Interleukin-8 receptor activitydefinition[GO:0004918]  
1
  • IDAUniProtKB
GO biological process 
Cell surface receptor signaling pathwaydefinition[GO:0007166]  
1
  • IDAUniProtKB
Chemokine-mediated signaling pathwaydefinition[GO:0070098]  
1
  • TASGOC
  • IEAInterPro 2 GO
Chemotaxisdefinition[GO:0006935]  
1
  • TASPINC
Dendritic cell chemotaxisdefinition[GO:0002407]  
1
  • TASBHF-UCL
G-protein coupled receptor signaling pathwaydefinition[GO:0007186]  
  • IEAUniProtKB KW
Inflammatory responsedefinition[GO:0006954]  
1
  • TASPINC
Interleukin-8-mediated signaling pathwaydefinition[GO:0038112]  
1
  • IDAGOC
Receptor internalizationdefinition[GO:0031623]  
1
  • IDAUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Chemokine signaling pathway  hsa04062+3577  
Cytokine-cytokine receptor interaction  hsa04060+3577  
Endocytosis  hsa04144+3577  
Epithelial cell signaling in Helicobacter pylori infection  hsa05120+3577  
According to Reactome, this protein belongs to the following pathways:
Chemokine receptors bind chemokines  REACT_15344  
G alpha (i) signalling events  REACT_19231  
 

Keywords

Biological process 
Chemotaxis  definition   [KW-0145]
Molecular function 
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Interleukin_8_receptor,_alpha
GenomeRNAi: 3577
PRO: PR:P25024
Chemistry
GuidetoPHARMACOLOGY: 68