CXCR2 - C-X-C chemokine receptor type 2 - human protein (Function)
 
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CXCR2 »  C-X-C chemokine receptor type 2  (CXCR-2)
 
Protein also known as:  High affinity interleukin-8 receptor B (IL-8R B); CD antigen CD182.
Gene name:  CXCR2
Entry whose protein(s) existence is based on evidence at protein level
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1 146 1
GENE REF ISO

Function

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Overview 
Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2.  
  • CuratedUniProtKB
GO molecular function 
C-X-C chemokine receptor activitydefinition[GO:0016494]  
1
  • IDAUniProtKB
Interleukin-8 bindingdefinition[GO:0019959]  
1
  • IPIUniProtKB
Interleukin-8 receptor activitydefinition[GO:0004918]  
1
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
1
  • IPIIntAct
Signal transducer activitydefinition[GO:0004871]  
3
  • IDAUniProtKB
GO biological process 
Acute inflammatory response to antigenic stimulusdefinition[GO:0002438] silver  
  • IEAOrtholog Compara
Cell surface receptor signaling pathwaydefinition[GO:0007166]  
2
  • IDAUniProtKB
Cellular defense responsedefinition[GO:0006968]  
1
  • IDAUniProtKB
Chemokine-mediated signaling pathwaydefinition[GO:0070098]  
1
  • IDAGOC
Chemotaxisdefinition[GO:0006935]  
1
  • IDAUniProtKB
Dendritic cell chemotaxisdefinition[GO:0002407]  
1
  • TASBHF-UCL
Inflammatory responsedefinition[GO:0006954]  
1
  • TASPINC
Interleukin-8-mediated signaling pathwaydefinition[GO:0038112]  
1
  • IDAGOC
Metanephric tubule morphogenesisdefinition[GO:0072173] silver  
  • IEAOrtholog Compara
Midbrain developmentdefinition[GO:0030901] silver  
  • IEAOrtholog Compara
Negative regulation of neutrophil apoptotic processdefinition[GO:0033030] silver  
  • IEAOrtholog Compara
Neutrophil activationdefinition[GO:0042119]  
1
  • IDAUniProtKB
Neutrophil chemotaxisdefinition[GO:0030593]  
1
  • IDAUniProtKB
Phospholipase C-activating G-protein coupled receptor signaling pathwaydefinition[GO:0007200]  
1
  • IDAUniProtKB
Positive regulation of angiogenesisdefinition[GO:0045766] silver  
  • IEAOrtholog Compara
Positive regulation of cardiac muscle cell apoptotic processdefinition[GO:0010666] silver  
  • IEAOrtholog Compara
Positive regulation of cell proliferationdefinition[GO:0008284]  
1
  • IDAUniProtKB
Positive regulation of cytosolic calcium ion concentrationdefinition[GO:0007204] silver  
  • IEAOrtholog Compara
Positive regulation of neutrophil chemotaxisdefinition[GO:0090023] silver  
  • IEAOrtholog Compara
Positive regulation of vascular permeabilitydefinition[GO:0043117] silver  
  • IEAOrtholog Compara
Receptor internalizationdefinition[GO:0031623]  
1
  • IDAUniProtKB
Signal transductiondefinition[GO:0007165]  
1
  • IDAUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Chemokine signaling pathway  hsa04062+3579  
Cytokine-cytokine receptor interaction  hsa04060+3579  
Endocytosis  hsa04144+3579  
Epithelial cell signaling in Helicobacter pylori infection  hsa05120+3579  
According to Reactome, this protein belongs to the following pathway:
Signal Transduction  REACT_111102  
 

Keywords

Biological process 
Chemotaxis  definition   [KW-0145]
Molecular function 
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GenomeRNAi: 3579
PRO: PR:P25025
Chemistry
GuidetoPHARMACOLOGY: 69