APC - Adenomatous polyposis coli protein - human protein (Function)
 
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APC »  Adenomatous polyposis coli protein  (Protein APC)
 
Protein also known as:  Deleted in polyposis 2.5.
Gene name:  APC
Entry whose protein(s) existence is based on evidence at protein level
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1 576 2
GENE REF ISO

Function

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Overview 
Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization.  
5
  • CuratedUniProtKB
GO molecular function 
Beta-catenin bindingdefinition[GO:0008013]  
4
  • IPIUniProtKB
  • IPIBHF-UCL
Not  Cadherin bindingdefinition[GO:0045296]  
1
  • IDABHF-UCL
Gamma-catenin bindingdefinition[GO:0045295]  
1
  • IPIBHF-UCL
Microtubule bindingdefinition[GO:0008017]  
2
  • IDAUniProtKB
Microtubule plus-end bindingdefinition[GO:0051010]  
1
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
26
  • IPIIntAct
  • IPIUniProtKB
Protein kinase bindingdefinition[GO:0019901]  
1
  • IPIUniProtKB
Protein kinase regulator activitydefinition[GO:0019887]  
1
  • IDAUniProtKB
GO biological process 
Anterior/posterior pattern specificationdefinition[GO:0009952] silver  
  • IEAOrtholog Compara
Axis specificationdefinition[GO:0009798] silver  
  • IEAOrtholog Compara
Axonogenesisdefinition[GO:0007409] silver  
  • IEAOrtholog Compara
Canonical Wnt signaling pathwaydefinition[GO:0060070]  
2
  • NASUniProtKB
Canonical Wnt signaling pathway involved in negative regulation of apoptotic processdefinition[GO:0044336] silver  
  • IEAOrtholog Compara
Canonical Wnt signaling pathway involved in positive regulation of apoptotic processdefinition[GO:0044337] silver  
  • IEAOrtholog Compara
Cell adhesiondefinition[GO:0007155]  
1
  • NASUniProtKB
Cell cycle arrestdefinition[GO:0007050]  
1
  • IDAUniProtKB
Cell migrationdefinition[GO:0016477]  
1
  • IMPUniProtKB
Cellular response to DNA damage stimulusdefinition[GO:0006974]  
1
  • IDAUniProtKB
Chromosome organizationdefinition[GO:0051276] silver  
  • IEAOrtholog Compara
Cytoplasmic microtubule organizationdefinition[GO:0031122] silver  
  • IEAOrtholog Compara
Dorsal/ventral pattern formationdefinition[GO:0009953] silver  
  • IEAOrtholog Compara
Hair follicle developmentdefinition[GO:0001942] silver  
  • IEAOrtholog Compara
Kidney developmentdefinition[GO:0001822] silver  
  • IEAOrtholog Compara
Metaphase/anaphase transition of mitotic cell cycledefinition[GO:0007091] silver  
  • IEAOrtholog Compara
Mitotic cytokinesisdefinition[GO:0000281]  
1
  • IMPMGI
Mitotic spindle assembly checkpointdefinition[GO:0007094]  
1
  • IMPMGI
Muscle cell cellular homeostasisdefinition[GO:0046716] silver  
  • IEAOrtholog Compara
Negative regulation of canonical Wnt signaling pathwaydefinition[GO:0090090]  
1
  • IGIMGI
Negative regulation of cell proliferationdefinition[GO:0008285]  
1
  • IDAUniProtKB
Negative regulation of cyclin-dependent protein serine/threonine kinase activitydefinition[GO:0045736]  
1
  • IDAUniProtKB
Negative regulation of epithelial cell proliferation involved in prostate gland developmentdefinition[GO:0060770] silver  
  • IEAOrtholog Compara
Negative regulation of MAPK cascadedefinition[GO:0043409] silver  
  • IEAOrtholog Compara
Negative regulation of microtubule depolymerizationdefinition[GO:0007026]  
2
  • IMPMGI
  • IDAUniProtKB
Negative regulation of odontogenesisdefinition[GO:0042483] silver  
  • IEAOrtholog Compara
Positive regulation of apoptotic processdefinition[GO:0043065]  
1
  • IMPMGI
Positive regulation of cell adhesiondefinition[GO:0045785] silver  
  • IEAOrtholog Compara
Positive regulation of cell divisiondefinition[GO:0051781] silver  
  • IEAOrtholog Compara
Positive regulation of cell migrationdefinition[GO:0030335]  
1
  • IMPMGI
Positive regulation of epithelial cell differentiationdefinition[GO:0030858] silver  
  • IEAOrtholog Compara
Positive regulation of microtubule polymerizationdefinition[GO:0031116] silver  
  • IEAOrtholog Compara
Positive regulation of protein catabolic processdefinition[GO:0045732]  
2
  • ICBHF-UCL
  • IGIMGI
Positive regulation of pseudopodium assemblydefinition[GO:0031274]  
1
  • IMPMGI
Protein complex assemblydefinition[GO:0006461]  
1
  • IDAUniProtKB
Proximal/distal pattern formationdefinition[GO:0009954] silver  
  • IEAOrtholog Compara
Regulation of attachment of spindle microtubules to kinetochoredefinition[GO:0051988]  
2
  • IMPMGI
  • NASUniProtKB
Regulation of microtubule-based processdefinition[GO:0032886]  
1
  • IMPUniProtKB
Regulation of nitrogen compound metabolic processdefinition[GO:0051171] silver  
  • IEAOrtholog Compara
Regulation of osteoblast differentiationdefinition[GO:0045667] silver  
  • IEAOrtholog Compara
Regulation of osteoclast differentiationdefinition[GO:0045670] silver  
  • IEAOrtholog Compara
Retina development in camera-type eyedefinition[GO:0060041] silver  
  • IEAOrtholog Compara
Somatic stem cell maintenancedefinition[GO:0035019] silver  
  • IEAOrtholog Compara
T cell differentiation in thymusdefinition[GO:0033077] silver  
  • IEAOrtholog Compara
Thymus developmentdefinition[GO:0048538] silver  
  • IEAOrtholog Compara
Tight junction assemblydefinition[GO:0070830]  
1
  • NASUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Basal cell carcinoma  hsa05217+324  
Colorectal cancer  hsa05210+324  
Endometrial cancer  hsa05213+324  
HTLV-I infection  hsa05166+324  
Pathways in cancer  hsa05200+324  
Regulation of actin cytoskeleton  hsa04810+324  
Wnt signaling pathway  hsa04310+324  
According to Reactome, this protein belongs to the following pathways:
Apoptotic cleavage of cellular proteins  REACT_107  
Beta-catenin phosphorylation cascade  REACT_11065  
deactivation of the beta-catenin transactivating complex  REACT_200731  
Degradation of beta-catenin by the destruction complex  REACT_11063  
disassembly of the destruction complex and recruitment of AXIN to the membrane  REACT_200610  
 
More information is available from:
Note 
APC mutations have led to some interesting observations. (1) the great majority of the mutations found to date would result in truncation of the APC product. (2) almost all the mutations have occurred within the first half of the coding sequence, and somatic mutations in colorectal tumors are further clustered in a particular region, called MCR (mutation cluster region). (3) most identified point mutations in the APC gene are transitions from cytosine to other nucleotides. (4) the location of germline mutations tends to correlate with the number of colorectal polyps in FAP patients. Inactivation of both alleles of the APC gene seems to be required as an early event to develop most adenomas and carcinomas in the colon and rectum as well as some of those in the stomach.  
  • CuratedUniProtKB
 

Keywords

Biological process 
Wnt signaling pathway  definition   [KW-0879]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Adenomatous_polyposis_coli
GenomeRNAi: 324
PRO: PR:P25054