FPR3 - N-formyl peptide receptor 3 - human protein (Function)
 
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FPR3 »  N-formyl peptide receptor 3
 
Protein also known as:  Formyl peptide receptor-like 2.
Gene name:  FPR3
Entry whose protein(s) existence is based on evidence at protein level
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1 33 1
GENE REF ISO

Function

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Overview 
Low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophils chemotactic factors. Binding of FMLP to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system.  
  • CuratedUniProtKB
GO molecular function 
N-formyl peptide receptor activitydefinition[GO:0004982] silver  
  • IEAInterPro 2 GO
GO biological process 
Cellular component movementdefinition[GO:0006928]  
1
  • TASPINC
Chemotaxisdefinition[GO:0006935]  
  • IEAUniProtKB KW
Signal transductiondefinition[GO:0007165]  
1
  • TASPINC
Pathways 
According to KEGG, this protein belongs to the following pathways:
Neuroactive ligand-receptor interaction  hsa04080+2359  
Staphylococcus aureus infection  hsa05150+2359  
According to Reactome, this protein belongs to the following pathway:
Signal Transduction  REACT_111102  
 

Keywords

Biological process 
Chemotaxis  definition   [KW-0145]
Molecular function 
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Formyl_peptide_receptor_3
GenomeRNAi: 2359
PRO: PR:P25089
Chemistry
GuidetoPHARMACOLOGY: 224