FPR2 - N-formyl peptide receptor 2 - human protein (Function)
 
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FPR2 »  N-formyl peptide receptor 2
 
Protein also known as:  Formyl peptide receptor-like 1.
Gene name:  FPR2
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 94 1
GENE REF ISO

Function

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Overview 
Low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophils chemotactic factors. Binding of FMLP to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The activation of LXA4R could result in an anti-inflammatory outcome counteracting the actions of proinflammatory signals such as LTB4 (leukotriene B4).  
  • CuratedUniProtKB
GO molecular function 
G-protein coupled receptor activitydefinition[GO:0004930]  
1
  • TASPINC
N-formyl peptide receptor activitydefinition[GO:0004982] silver  
  • IEAInterPro 2 GO
GO biological process 
Cell adhesiondefinition[GO:0007155]  
1
  • TASPINC
Cellular component movementdefinition[GO:0006928]  
1
  • TASPINC
Chemotaxisdefinition[GO:0006935]  
  • IEAUniProtKB KW
G-protein coupled receptor signaling pathwaydefinition[GO:0007186]  
  • IEAUniProtKB KW
Inflammatory responsedefinition[GO:0006954]  
1
  • TASPINC
Pathways 
According to KEGG, this protein belongs to the following pathways:
Neuroactive ligand-receptor interaction  hsa04080+2358  
Staphylococcus aureus infection  hsa05150+2358  
According to Reactome, this protein belongs to the following pathways:
Formyl peptide receptors bind formyl peptides and many other ligands  REACT_21264  
G alpha (i) signalling events  REACT_19231  
G alpha (q) signalling events  REACT_18283  
 

Keywords

Biological process 
Chemotaxis  definition   [KW-0145]
Molecular function 
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Formyl_peptide_receptor_2
GenomeRNAi: 2358
PRO: PR:P25090
Chemistry
GuidetoPHARMACOLOGY: 223