GUCY2C - Heat-stable enterotoxin receptor - human protein (Function)
 
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Protein
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GUCY2C »  Heat-stable enterotoxin receptor   [ EC 4.6.1.2 ]  (STA receptor)
 
Protein also known as:  Intestinal guanylate cyclase.
Gene name:  GUCY2C
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Receptor for the E.coli heat-stable enterotoxin (E.coli enterotoxin markedly stimulates the accumulation of cGMP in mammalian cells expressing GC-C). Also activated by the endogenous peptides guanylin and uroguanylin.  
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524] silver  
  • IEAInterPro 2 GO
GTP bindingdefinition[GO:0005525]  
  • IEAUniProtKB KW
Guanylate cyclase activitydefinition[GO:0004383]  
  • IEAEC 2 GO
Protein bindingdefinition[GO:0005515]  
1
  • IPIIntAct
Protein kinase activitydefinition[GO:0004672] silver  
  • IEAInterPro 2 GO
Toxic substance bindingdefinition[GO:0015643] silver  
  • IEAOrtholog Compara
GO biological process 
cGMP biosynthetic processdefinition[GO:0006182] silver  
  • IEAOrtholog Compara
Intracellular signal transductiondefinition[GO:0035556] silver  
  • IEAInterPro 2 GO
Protein phosphorylationdefinition[GO:0006468] silver  
  • IEAInterPro 2 GO
Receptor guanylyl cyclase signaling pathwaydefinition[GO:0007168]  
1
  • TASPINC
Regulation of cell proliferationdefinition[GO:0042127] silver  
  • IEAOrtholog Compara
Response to toxic substancedefinition[GO:0009636] silver  
  • IEAOrtholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 4.6.1.2: GTP 3',5'-cyclic GMP + diphosphate.  
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathway:
Purine metabolism  hsa00230+2984  
 

Keywords

Biological process 
cGMP biosynthesis  definition   [KW-0141]
Molecular function 
Lyase  definition   [KW-0456]
Receptor  definition   [KW-0675]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Guanylate_cyclase_2C
GenomeRNAi: 2984
PRO: PR:P25092
Chemistry
GuidetoPHARMACOLOGY: 1750