ADRBK1 - Beta-adrenergic receptor kinase 1 - human protein (Function)
 
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ADRBK1 »  Beta-adrenergic receptor kinase 1   [ EC 2.7.11.15 ]  (Beta-ARK-1)
 
Protein also known as:  G-protein coupled receptor kinase 2.
Gene name:  ADRBK1
Entry whose protein(s) existence is based on evidence at protein level
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1 157 1
GENE REF ISO

Function

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Overview 
Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner.  
2
  • UniProtKB
GO molecular function 
Alpha-2A adrenergic receptor bindingdefinition[GO:0031694]  
1
  • Ortholog Curator
ATP bindingdefinition[GO:0005524]  
1
  • UniProtKB KW
Beta-adrenergic receptor kinase activitydefinition[GO:0047696]  
1
  • EC 2 GO
Edg-2 lysophosphatidic acid receptor bindingdefinition[GO:0031755]  
1
  • UniProtKB
G-protein coupled receptor kinase activitydefinition[GO:0004703]  
1
  • Ortholog Curator
Protein bindingdefinition[GO:0005515]  
5
  • IntAct
  • UniProtKB
  • BHF-UCL
Protein kinase activitydefinition[GO:0004672]  
1
  • Ortholog Curator
GO biological process 
Cardiac muscle contractiondefinition[GO:0060048]  
1
  • BHF-UCL
Desensitization of G-protein coupled receptor protein signaling pathwaydefinition[GO:0002029]  
1
  • Ortholog Curator
G-protein coupled acetylcholine receptor signaling pathwaydefinition[GO:0007213]  
1
  • Ortholog Curator
Heart developmentdefinition[GO:0007507] silver  
1
  • Ortholog Compara
Negative regulation of striated muscle contractiondefinition[GO:0045988]  
1
  • BHF-UCL
Negative regulation of the force of heart contraction by chemical signaldefinition[GO:0003108]  
1
  • BHF-UCL
Peptidyl-serine phosphorylationdefinition[GO:0018105]  
1
  • Ortholog Curator
Peptidyl-threonine phosphorylationdefinition[GO:0018107] silver  
1
  • Ortholog Compara
Positive regulation of catecholamine secretiondefinition[GO:0033605]  
1
  • Ortholog Curator
Receptor internalizationdefinition[GO:0031623]  
1
  • UniProtKB
Tachykinin receptor signaling pathwaydefinition[GO:0007217]  
1
  • BHF-UCL
Termination of G-protein coupled receptor signaling pathwaydefinition[GO:0038032] silver  
1
  • InterPro 2 GO
Viral entry into host celldefinition[GO:0046718] silver  
1
  • CACAO
Viral genome replicationdefinition[GO:0019079] silver  
1
  • CACAO
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.11.15: ATP + [beta-adrenergic receptor] ADP + [beta-adrenergic receptor] phosphate.  
1
  • UniProtKB
It is regulated in the following manner
In contrast to other AGC family kinases, the catalytic activity is solely regulated by the binding of substrates and ligands, not by phosphorylation of the kinase domain.  
2
  • UniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Chemokine signaling pathway  hsa04062+156  
Endocytosis  hsa04144+156  
Glutamatergic synapse  hsa04724+156  
According to Reactome, this protein belongs to the following pathways:
Activation of SMO  REACT_267753  
Calmodulin induced events  REACT_9000  
G alpha (q) signalling events  REACT_18283  
 

Keywords

Molecular function 
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Beta_adrenergic_receptor_kinase
GenomeRNAi: 156
PRO: PR:P25098
Chemistry
GuidetoPHARMACOLOGY: 1466