ADRBK1 - Beta-adrenergic receptor kinase 1 - human protein (Function)
 
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ADRBK1 »  Beta-adrenergic receptor kinase 1   [ EC 2.7.11.15 ]  (Beta-ARK-1)
 
Protein also known as:  G-protein coupled receptor kinase 2.
Gene name:  ADRBK1
Entry whose protein(s) existence is based on evidence at protein level
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1 132 1
GENE REF ISO

Function

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Overview 
Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner.  
1
  • CuratedUniProtKB
GO molecular function 
Alpha-2A adrenergic receptor bindingdefinition[GO:0031694]  
  • ISSOrtholog Curator
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Beta-adrenergic receptor kinase activitydefinition[GO:0047696]  
  • IEAEC 2 GO
Edg-2 lysophosphatidic acid receptor bindingdefinition[GO:0031755]  
1
  • IDAUniProtKB
G-protein coupled receptor kinase activitydefinition[GO:0004703]  
  • ISSOrtholog Curator
Protein bindingdefinition[GO:0005515]  
5
  • IPIIntAct
  • IPIUniProtKB
  • IPIBHF-UCL
Protein kinase activitydefinition[GO:0004672]  
  • ISSOrtholog Curator
GO biological process 
Cardiac muscle contractiondefinition[GO:0060048]  
1
  • IMPBHF-UCL
Desensitization of G-protein coupled receptor protein signaling pathwaydefinition[GO:0002029]  
  • ISSOrtholog Curator
G-protein coupled acetylcholine receptor signaling pathwaydefinition[GO:0007213]  
  • ISSOrtholog Curator
Heart developmentdefinition[GO:0007507] silver  
  • IEAOrtholog Compara
Negative regulation of striated muscle contractiondefinition[GO:0045988]  
1
  • IMPBHF-UCL
Negative regulation of the force of heart contraction by chemical signaldefinition[GO:0003108]  
1
  • IMPBHF-UCL
Peptidyl-serine phosphorylationdefinition[GO:0018105]  
  • ISSOrtholog Curator
Peptidyl-threonine phosphorylationdefinition[GO:0018107] silver  
  • IEAOrtholog Compara
Positive regulation of catecholamine secretiondefinition[GO:0033605]  
  • ISSOrtholog Curator
Receptor internalizationdefinition[GO:0031623]  
1
  • IDAUniProtKB
Tachykinin receptor signaling pathwaydefinition[GO:0007217]  
1
  • IDABHF-UCL
Termination of G-protein coupled receptor signaling pathwaydefinition[GO:0038032] silver  
  • IEAInterPro 2 GO
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.11.15: ATP + [beta-adrenergic receptor] ADP + [beta-adrenergic receptor] phosphate.  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Chemokine signaling pathway  hsa04062+156  
Endocytosis  hsa04144+156  
Glutamatergic synapse  hsa04724+156  
According to Reactome, this protein belongs to the following pathways:
Disease  REACT_116125  
Immune System  REACT_6900  
Signal Transduction  REACT_111102  
 

Keywords

Molecular function 
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Beta_adrenergic_receptor_kinase
GenomeRNAi: 156
PRO: PR:P25098
Chemistry
GuidetoPHARMACOLOGY: 1466