ACKR3 - Atypical chemokine receptor 3 - human protein (Function)
 
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Protein
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ACKR3 »  Atypical chemokine receptor 3
 
Protein also known as:  G-protein coupled receptor RDC1 homolog (RDC-1).
Gene name:  ACKR3
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 55 1
GENE REF ISO

Function

 show evidences
Overview 
Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines CXCL11 and CXCL12/SDF1. Chemokine binding does not activate G-protein-mediated signal transduction but instead induces beta-arrestin recruitment, leading to ligand internalization and activation of MAPK signaling pathway. Required for regulation of CXCR4 protein levels in migrating interneurons, thereby adapting their chemokine responsiveness. In glioma cells, transduces signals via MEK/ERK pathway, mediating resistance to apoptosis. Promotes cell growth and survival. Not involved in cell migration, adhesion or proliferation of normal hematopoietic progenitors but activated by CXCL11 in malignant hemapoietic cells, leading to phosphorylation of ERK1/2 (MAPK3/MAPK1) and enhanced cell adhesion and migration. Plays a regulatory role in CXCR4-mediated activation of cell surface integrins by CXCL12. Required for heart valve development. Acts as coreceptor with CXCR4 for a restricted number of HIV isolates.  
13
  • CuratedUniProtKB
GO molecular function 
C-X-C chemokine bindingdefinition[GO:0019958]  
1
  • IMPUniProtKB
C-X-C chemokine receptor activitydefinition[GO:0016494]  
1
  • IMPBHF-UCL
Coreceptor activitydefinition[GO:0015026] silver  
  • IEAInterPro 2 GO
Protein bindingdefinition[GO:0005515]  
2
  • IPIUniProtKB
Scavenger receptor activitydefinition[GO:0005044]  
1
  • IMPUniProtKB
GO biological process 
Angiogenesisdefinition[GO:0001525] silver  
  • IEAInterPro 2 GO
Cell adhesiondefinition[GO:0007155]  
  • IEAUniProtKB KW
Chemokine-mediated signaling pathwaydefinition[GO:0070098]  
1
  • IMPBHF-UCL
Chemotaxisdefinition[GO:0006935] silver  
  • IEAInterPro 2 GO
G-protein coupled receptor signaling pathwaydefinition[GO:0007186]  
  • IEAUniProtKB KW
Negative regulation of intrinsic apoptotic signaling pathway in response to DNA damagedefinition[GO:1902230]  
1
  • IMPBHF-UCL
Positive regulation of ERK1 and ERK2 cascadedefinition[GO:0070374]  
1
  • IMPUniProtKB
Receptor internalizationdefinition[GO:0031623]  
2
  • IMPUniProtKB
Vasculogenesisdefinition[GO:0001570] silver  
  • IEAInterPro 2 GO
Viral processdefinition[GO:0016032]  
  • IEAUniProtKB KW
Pathways 
According to KEGG, this protein belongs to the following pathway:
Cytokine-cytokine receptor interaction  hsa04060+57007  
According to Reactome, this protein belongs to the following pathways:
Chemokine receptors bind chemokines  REACT_15344  
G alpha (i) signalling events  REACT_19231  
Caution 
Was originally (PubMed1675791) thought to be the receptor for VIP.  
1
  • CuratedUniProtKB
 

Keywords

Biological process 
Cell adhesion  definition   [KW-0130]
Host-virus interaction  definition   [KW-0945]
Molecular function 
Developmental protein  definition   [KW-0217]
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: CXCR7
GenomeRNAi: 57007
PRO: PR:P25106
Chemistry
GuidetoPHARMACOLOGY: 80