LAMA1 - Laminin subunit alpha-1 - human protein (Function)
 
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Protein
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LAMA1 »  Laminin subunit alpha-1
 
Protein also known as:  S-laminin subunit alpha (S-LAM alpha).
Gene name:  LAMA1
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.  
  • CuratedUniProtKB
GO molecular function 
Extracellular matrix structural constituentdefinition[GO:0005201]  
  • ISSOrtholog Curator
Glycosphingolipid bindingdefinition[GO:0043208] silver  
  • IEAOrtholog Compara
Protein bindingdefinition[GO:0005515]  
1
  • IPIIntAct
Receptor bindingdefinition[GO:0005102] silver  
  • IEAInterPro 2 GO
GO biological process 
Branching involved in salivary gland morphogenesisdefinition[GO:0060445] silver  
  • IEAOrtholog Compara
Cell adhesiondefinition[GO:0007155]  
  • IEAUniProtKB KW
Cell surface receptor signaling pathwaydefinition[GO:0007166]  
  • ISSOrtholog Curator
Epithelial tube branching involved in lung morphogenesisdefinition[GO:0060441] silver  
  • IEAOrtholog Compara
Establishment of epithelial cell apical/basal polaritydefinition[GO:0045198] silver  
  • IEAOrtholog Compara
Morphogenesis of an epithelial sheetdefinition[GO:0002011] silver  
  • IEAOrtholog Compara
Regulation of cell adhesiondefinition[GO:0030155] silver  
  • IEAInterPro 2 GO
Regulation of cell migrationdefinition[GO:0030334] silver  
  • IEAInterPro 2 GO
Regulation of embryonic developmentdefinition[GO:0045995] silver  
  • IEAInterPro 2 GO
Retinal blood vessel morphogenesisdefinition[GO:0061304] silver  
  • IEAOrtholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathways:
Amoebiasis  hsa05146+284217  
ECM-receptor interaction  hsa04512+284217  
Focal adhesion  hsa04510+284217  
Pathways in cancer  hsa05200+284217  
Small cell lung cancer  hsa05222+284217  
Toxoplasmosis  hsa05145+284217  
According to Reactome, this protein belongs to the following pathways:
Developmental Biology  REACT_111045  
Extracellular matrix organization  REACT_118779  
 

Keywords

Biological process 
Cell adhesion  definition   [KW-0130]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Laminin,_alpha_1
GenomeRNAi: 284217
PRO: PR:P25391