DNAJB2 - DnaJ homolog subfamily B member 2 - human protein (Function)
 
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DNAJB2 »  DnaJ homolog subfamily B member 2
 
Protein also known as:  Heat shock 40 kDa protein 3.
Gene name:  DNAJB2
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 26 2
GENE REF ISO

Function

 show evidences
GO molecular function 
Chaperone bindingdefinition[GO:0051087]  
1
  • IPIUniProtKB
Isoform  Iso 2   Hsp70 protein bindingdefinition[GO:0030544]  
1
  • IPIBHF-UCL
Isoform  Iso 2   Polyubiquitin bindingdefinition[GO:0031593]  
1
  • IDABHF-UCL
Isoform  Iso 2   Proteasome bindingdefinition[GO:0070628]  
1
  • IDABHF-UCL
Isoform  Iso 3   Protein bindingdefinition[GO:0005515]  
1
  • IPIBHF-UCL
Unfolded protein bindingdefinition[GO:0051082]  
1
  • IDAUniProtKB
GO biological process 
Cell deathdefinition[GO:0008219]  
  • IEAUniProtKB KW
Isoform  Iso 3   ER-associated ubiquitin-dependent protein catabolic processdefinition[GO:0030433]  
1
  • IDABHF-UCL
Negative regulation of cell growthdefinition[GO:0030308]  
1
  • IGIUniProtKB
Negative regulation of cell proliferationdefinition[GO:0008285]  
1
  • IGIUniProtKB
Negative regulation of inclusion body assemblydefinition[GO:0090084]  
2
  • IDAUniProtKB
  • IDABHF-UCL
Isoform  Iso 2   Negative regulation of protein deubiquitinationdefinition[GO:0090086]  
1
  • IDABHF-UCL
Isoform  Iso 3   Positive regulation of proteasomal ubiquitin-dependent protein catabolic processdefinition[GO:0032436]  
1
  • IDABHF-UCL
Isoform  Iso 2   Positive regulation of protein ubiquitinationdefinition[GO:0031398]  
1
  • IDABHF-UCL
Protein foldingdefinition[GO:0006457]  
1
  • TASPINC
Protein refoldingdefinition[GO:0042026]  
1
  • IDAUniProtKB
Response to unfolded proteindefinition[GO:0006986]  
1
  • TASPINC
Pathways 
According to KEGG, this protein belongs to the following pathway:
Protein processing in endoplasmic reticulum  hsa04141+3300  
 

Keywords

Molecular function 
Chaperone  definition   [KW-0143]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: DNAJB2
GenomeRNAi: 3300
PRO: PR:P25686