CTSS - Cathepsin S - human protein (Function)
 
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Protein
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CTSS »  Cathepsin S
 
Gene name:  CTSS
Family name: Peptidase C1
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L and cathepsin N.  
  • CuratedUniProtKB
GO molecular function 
Collagen bindingdefinition[GO:0005518]  
1
  • IDABHF-UCL
Cysteine-type endopeptidase activitydefinition[GO:0004197]  
1
  • IDABHF-UCL
Fibronectin bindingdefinition[GO:0001968]  
1
  • IPIBHF-UCL
Laminin bindingdefinition[GO:0043236]  
1
  • IDABHF-UCL
Proteoglycan bindingdefinition[GO:0043394]  
1
  • IPIBHF-UCL
GO biological process 
Adaptive immune responsedefinition[GO:0002250]  
1
  • IEPUniProtKB
Antigen processing and presentationdefinition[GO:0019882]  
1
  • TASUniProtKB
Basement membrane disassemblydefinition[GO:0034769]  
1
  • IDABHF-UCL
Cellular response to thyroid hormone stimulusdefinition[GO:0097067]  
1
  • IEPUniProtKB
Collagen catabolic processdefinition[GO:0030574]  
1
  • IDABHF-UCL
Immune responsedefinition[GO:0006955]  
1
  • TASPINC
Proteolysisdefinition[GO:0006508]  
1
  • TASPINC
Proteolysis involved in cellular protein catabolic processdefinition[GO:0051603]  
1
  • IDABHF-UCL
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.4.22.27: Similar to cathepsin L, but with much less activity on Z-Phe-Arg-|-NHMec, and more activity on the Z-Val-Val-Arg-|-Xaa compound.  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Antigen processing and presentation  hsa04612+1520  
Lysosome  hsa04142+1520  
Phagosome  hsa04145+1520  
Tuberculosis  hsa05152+1520  
According to Reactome, this protein belongs to the following pathways:
Assembly of collagen fibrils and other multimeric structures  REACT_150180  
Degradation of the extracellular matrix  REACT_118572  
Endosomal/Vacuolar pathway  REACT_111168  
MHC class II antigen presentation  REACT_121399  
Trafficking and processing of endosomal TLR  REACT_118632  
 

Keywords

Molecular function 
Hydrolase  definition   [KW-0378]
Protease  definition   [KW-0645]
Thiol protease  definition   [KW-0788]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Cathepsin_S
GenomeRNAi: 1520
PRO: PR:P25774
Chemistry
GuidetoPHARMACOLOGY: 2353