CD40 - Tumor necrosis factor receptor superfamily member 5 - human protein (Function)
 
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CD40 »  Tumor necrosis factor receptor superfamily member 5
 
Protein also known as:  CD antigen CD40.
Gene name:  CD40
Entry whose protein(s) existence is based on evidence at protein level
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1 347 2
GENE REF ISO

Function

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Overview 
Receptor for TNFSF5/CD40LG. Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion.  
  • CuratedUniProtKB
GO molecular function 
Antigen bindingdefinition[GO:0003823] silver  
  • IEAOrtholog Compara
Enzyme bindingdefinition[GO:0019899]  
1
  • IPIUniProtKB
Protein bindingdefinition[GO:0005515]  
4
  • IPIIntAct
  • IPIUniProtKB
Receptor activitydefinition[GO:0004872]  
1
  • TASPINC
Signal transducer activitydefinition[GO:0004871]  
1
  • TASPINC
Ubiquitin protein ligase bindingdefinition[GO:0031625]  
1
  • IPIUniProtKB
GO biological process 
B cell proliferationdefinition[GO:0042100]  
1
  • NASUniProtKB
Cellular calcium ion homeostasisdefinition[GO:0006874]  
1
  • IMPBHF-UCL
Cellular response to lipopolysaccharidedefinition[GO:0071222] silver  
  • IEAOrtholog Compara
Cellular response to mechanical stimulusdefinition[GO:0071260]  
1
  • IEPUniProtKB
Defense response to virusdefinition[GO:0051607] silver  
  • IEAOrtholog Compara
Immune response-regulating cell surface receptor signaling pathwaydefinition[GO:0002768] silver  
  • IEAOrtholog Compara
Inflammatory responsedefinition[GO:0006954] silver  
  • IEAOrtholog Compara
Platelet activationdefinition[GO:0030168]  
1
  • NASUniProtKB
Positive regulation of B cell proliferationdefinition[GO:0030890] silver  
  • IEAOrtholog Compara
Positive regulation of Cdc42 GTPase activitydefinition[GO:0043089]  
1
  • IMPBHF-UCL
Positive regulation of endothelial cell apoptotic processdefinition[GO:2000353]  
1
  • IDABHF-UCL
Positive regulation of I-kappaB kinase/NF-kappaB signalingdefinition[GO:0043123]  
1
  • IEPUniProtKB
Positive regulation of interleukin-12 productiondefinition[GO:0032735] silver  
  • IEAOrtholog Compara
Positive regulation of isotype switching to IgG isotypesdefinition[GO:0048304] silver  
  • IEAOrtholog Compara
Positive regulation of MAP kinase activitydefinition[GO:0043406]  
1
  • IMPBHF-UCL
Positive regulation of NF-kappaB transcription factor activitydefinition[GO:0051092]  
1
  • IMPBHF-UCL
Positive regulation of protein kinase C signalingdefinition[GO:0090037]  
1
  • IMPBHF-UCL
Positive regulation of protein phosphorylationdefinition[GO:0001934]  
1
  • IMPBHF-UCL
Positive regulation of Rac GTPase activitydefinition[GO:0032855]  
1
  • IMPBHF-UCL
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
1
  • IMPBHF-UCL
Positive regulation of tyrosine phosphorylation of Stat1 proteindefinition[GO:0042511]  
1
  • IMPBHF-UCL
Protein complex assemblydefinition[GO:0006461]  
1
  • TASPINC
Regulation of immunoglobulin secretiondefinition[GO:0051023] silver  
  • IEAOrtholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathways:
Allograft rejection  hsa05330+958  
Asthma  hsa05310+958  
Autoimmune thyroid disease  hsa05320+958  
Cell adhesion molecules (CAMs)  hsa04514+958  
Cytokine-cytokine receptor interaction  hsa04060+958  
HTLV-I infection  hsa05166+958  
Intestinal immune network for IgA production  hsa04672+958  
Malaria  hsa05144+958  
Primary immunodeficiency  hsa05340+958  
Systemic lupus erythematosus  hsa05322+958  
Toll-like receptor signaling pathway  hsa04620+958  
Toxoplasmosis  hsa05145+958  
Viral myocarditis  hsa05416+958  
According to Reactome, this protein belongs to the following pathway:
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell  REACT_11152  
 

Keywords

Biological process 
Immunity  definition   [KW-0391]
Molecular function 
Receptor  definition   [KW-0675]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: CD40_(protein)
GenomeRNAi: 958
PRO: PR:P25942
Chemistry
GuidetoPHARMACOLOGY: 1874