NFKBIA - NF-kappa-B inhibitor alpha - human protein (Function)
 
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NFKBIA »  NF-kappa-B inhibitor alpha
 
Protein also known as:  Major histocompatibility complex enhancer-binding protein MAD3.
Gene name:  NFKBIA
Family name: NF-kappa-B inhibitor
Entry whose protein(s) existence is based on evidence at protein level
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1 326 1
GENE REF ISO

Function

 show evidences
Overview 
Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription.  
1
  • CuratedUniProtKB
GO molecular function 
Enzyme bindingdefinition[GO:0019899]  
1
  • IPIUniProtKB
Heat shock protein bindingdefinition[GO:0031072] silver  
  • IEAOrtholog Compara
Identical protein bindingdefinition[GO:0042802]  
1
  • IPIIntAct
NF-kappaB bindingdefinition[GO:0051059]  
2
  • IDAMGI
  • IPIUniProtKB
Nuclear localization sequence bindingdefinition[GO:0008139]  
1
  • IPIUniProtKB
Protein bindingdefinition[GO:0005515]  
34
  • IPIIntAct
  • IPIUniProtKB
  • IPIBHF-UCL
Protein complex bindingdefinition[GO:0032403] silver  
  • IEAOrtholog Compara
Transcription factor bindingdefinition[GO:0008134]  
1
  • TASPINC
Ubiquitin protein ligase bindingdefinition[GO:0031625]  
1
  • IPIUniProtKB
GO biological process 
Apoptotic processdefinition[GO:0006915]  
1
  • TASPINC
Cellular response to colddefinition[GO:0070417]  
1
  • NASBHF-UCL
Cytoplasmic sequestering of NF-kappaBdefinition[GO:0007253]  
1
  • IMPBHF-UCL
Cytoplasmic sequestering of transcription factordefinition[GO:0042994]  
1
  • IDAUniProtKB
Lipopolysaccharide-mediated signaling pathwaydefinition[GO:0031663] silver  
  • IEAOrtholog Compara
Negative regulation of DNA bindingdefinition[GO:0043392]  
1
  • NASUniProtKB
Negative regulation of lipid storagedefinition[GO:0010888]  
1
  • IMPBHF-UCL
Negative regulation of macrophage derived foam cell differentiationdefinition[GO:0010745]  
1
  • IMPBHF-UCL
Negative regulation of myeloid cell differentiationdefinition[GO:0045638] silver  
  • IEAOrtholog Compara
Negative regulation of NF-kappaB transcription factor activitydefinition[GO:0032088]  
1
  • IDAMGI
Negative regulation of Notch signaling pathwaydefinition[GO:0045746] silver  
  • IEAOrtholog Compara
Nucleotide-binding oligomerization domain containing 1 signaling pathwaydefinition[GO:0070427] silver  
  • IEAOrtholog Compara
Nucleotide-binding oligomerization domain containing 2 signaling pathwaydefinition[GO:0070431] silver  
  • IEAOrtholog Compara
Positive regulation of cellular protein metabolic processdefinition[GO:0032270]  
1
  • IMPBHF-UCL
Positive regulation of cholesterol effluxdefinition[GO:0010875]  
1
  • IMPBHF-UCL
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
2
  • IDAUniProtKB
  • IMPBHF-UCL
Protein import into nucleus, translocationdefinition[GO:0000060] silver  
  • IEAOrtholog Compara
Regulation of cell proliferationdefinition[GO:0042127] silver  
  • IEAOrtholog Compara
Regulation of NF-kappaB import into nucleusdefinition[GO:0042345]  
1
  • NASUniProtKB
Response to exogenous dsRNAdefinition[GO:0043330] silver  
  • IEAOrtholog Compara
Response to muramyl dipeptidedefinition[GO:0032495] silver  
  • IEAOrtholog Compara
Viral processdefinition[GO:0016032]  
  • IEAUniProtKB KW
Pathways 
According to KEGG, this protein belongs to the following pathways:
Adipocytokine signaling pathway  hsa04920+4792  
Apoptosis  hsa04210+4792  
B cell receptor signaling pathway  hsa04662+4792  
Chagas disease (American trypanosomiasis)  hsa05142+4792  
Chemokine signaling pathway  hsa04062+4792  
Chronic myeloid leukemia  hsa05220+4792  
Cytosolic DNA-sensing pathway  hsa04623+4792  
Epithelial cell signaling in Helicobacter pylori infection  hsa05120+4792  
Hepatitis C  hsa05160+4792  
Herpes simplex infection  hsa05168+4792  
HTLV-I infection  hsa05166+4792  
Influenza A  hsa05164+4792  
Legionellosis  hsa05134+4792  
Leishmaniasis  hsa05140+4792  
Measles  hsa05162+4792  
Neurotrophin signaling pathway  hsa04722+4792  
NOD-like receptor signaling pathway  hsa04621+4792  
Osteoclast differentiation  hsa04380+4792  
Pathways in cancer  hsa05200+4792  
Prostate cancer  hsa05215+4792  
RIG-I-like receptor signaling pathway  hsa04622+4792  
Shigellosis  hsa05131+4792  
Small cell lung cancer  hsa05222+4792  
T cell receptor signaling pathway  hsa04660+4792  
Toll-like receptor signaling pathway  hsa04620+4792  
Toxoplasmosis  hsa05145+4792  
According to Reactome, this protein belongs to the following pathways:
Activation of NF-kappaB in B cells  REACT_118656  
Downstream TCR signaling  REACT_12555  
FCERI mediated NF-kB activation  REACT_163994  
NF-kB is activated and signals survival  REACT_13696  
RIP-mediated NFkB activation via ZBP1  REACT_118563  
TAK1 activates NFkB by phosphorylation and activation of IKKs complex  REACT_21281  
TRAF6 mediated NF-kB activation  REACT_24969  
 

Keywords

Biological process 
Host-virus interaction  definition   [KW-0945]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: P25963
Other
GeneWiki: I%CE%BAB%CE%B1
GenomeRNAi: 4792
PRO: PR:P25963