MSN - Moesin - human protein (Function)
 
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Protein
Gene
References

 
MSN »  Moesin
 
Protein also known as:  Membrane-organizing extension spike protein.
Gene name:  MSN
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Probably involved in connections of major cytoskeletal structures to the plasma membrane. May inhibit herpes simplex virus 1 infection at an early stage.  
2
  • UniProtKB
GO molecular function 
Actin bindingdefinition[GO:0003779] silver  
1
  • InterPro 2 GO
Cell adhesion molecule bindingdefinition[GO:0050839]  
1
  • BHF-UCL
Double-stranded RNA bindingdefinition[GO:0003725]  
1
  • MGI
Protein bindingdefinition[GO:0005515]  
17
  • IntAct
  • UniProtKB
Protein kinase bindingdefinition[GO:0019901]  
1
  • UniProtKB
Receptor bindingdefinition[GO:0005102]  
1
  • UniProtKB
Structural constituent of cytoskeletondefinition[GO:0005200]  
1
  • PINC
GO biological process 
Cellular response to testosterone stimulusdefinition[GO:0071394]  
1
  • UniProtKB
Establishment of endothelial barrierdefinition[GO:0061028]  
1
  • UniProtKB
Establishment of epithelial cell apical/basal polaritydefinition[GO:0045198]  
1
  • UniProtKB
Gland morphogenesisdefinition[GO:0022612]  
1
  • UniProtKB
Leukocyte cell-cell adhesiondefinition[GO:0007159]  
1
  • BHF-UCL
Leukocyte migrationdefinition[GO:0050900]  
1
  • BHF-UCL
Membrane to membrane dockingdefinition[GO:0022614]  
1
  • BHF-UCL
Movement of cell or subcellular componentdefinition[GO:0006928]  
1
  • UniProtKB
Positive regulation of cellular protein catabolic processdefinition[GO:1903364]  
1
  • UniProtKB
Positive regulation of early endosome to late endosome transportdefinition[GO:2000643]  
1
  • UniProtKB
Positive regulation of gene expressiondefinition[GO:0010628]  
1
  • UniProtKB
Positive regulation of protein localization to early endosomedefinition[GO:1902966]  
1
  • UniProtKB
Regulation of cell shapedefinition[GO:0008360]  
1
  • UniProtKB
Contradiction  Regulation of cell sizedefinition[GO:0008361]  
2
  • UniProtKB
Regulation of lymphocyte migrationdefinition[GO:2000401]  
1
  • UniProtKB
Regulation of organelle assemblydefinition[GO:1902115]  
1
  • UniProtKB
Enzymatic activity 
It is regulated in the following manner
A head-to-tail association, of the N-terminal and C-terminal halves results in a closed conformation (inactive form) which is incapable of actin or membrane-binding.  
1
  • UniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Leukocyte transendothelial migration  hsa04670+4478  
Measles  hsa05162+4478  
Regulation of actin cytoskeleton  hsa04810+4478  
According to Reactome, this protein belongs to the following pathway:
Recycling pathway of L1  R-HSA-437239  
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Moesin
GenomeRNAi: 4478
PRO: PR:P26038