MSN - Moesin - human protein (Function)
 
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Protein
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MSN »  Moesin
 
Protein also known as:  Membrane-organizing extension spike protein.
Gene name:  MSN
Entry whose protein(s) existence is based on evidence at protein level
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1 136 1
GENE REF ISO

Function

 show evidences
Overview 
Probably involved in connections of major cytoskeletal structures to the plasma membrane. May inhibit herpes simplex virus 1 infection at an early stage.  
1
  • CuratedUniProtKB
GO molecular function 
Actin bindingdefinition[GO:0003779] silver  
  • IEAInterPro 2 GO
Cell adhesion molecule bindingdefinition[GO:0050839]  
1
  • IPIBHF-UCL
Double-stranded RNA bindingdefinition[GO:0003725]  
1
  • IDAMGI
Protein bindingdefinition[GO:0005515]  
12
  • IPIIntAct
  • IPIBHF-UCL
  • IPIUniProtKB
Protein kinase bindingdefinition[GO:0019901]  
1
  • IPIUniProtKB
Receptor bindingdefinition[GO:0005102]  
1
  • IPIUniProtKB
Structural constituent of cytoskeletondefinition[GO:0005200]  
1
  • TASPINC
GO biological process 
Cellular component movementdefinition[GO:0006928]  
1
  • TASUniProtKB
Establishment of endothelial barrierdefinition[GO:0061028]  
1
  • IGIUniProtKB
Leukocyte cell-cell adhesiondefinition[GO:0007159]  
1
  • IEPBHF-UCL
Leukocyte migrationdefinition[GO:0050900]  
1
  • IEPBHF-UCL
Membrane to membrane dockingdefinition[GO:0022614]  
1
  • IEPBHF-UCL
Positive regulation of gene expressiondefinition[GO:0010628]  
1
  • IGIUniProtKB
Regulation of lymphocyte migrationdefinition[GO:2000401]  
1
  • IMPUniProtKB
Enzymatic activity 
It is regulated in the following manner
A head-to-tail association, of the N-terminal and C-terminal halves results in a closed conformation (inactive form) which is incapable of actin or membrane-binding (By similarity).  
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Leukocyte transendothelial migration  hsa04670+4478  
Measles  hsa05162+4478  
Regulation of actin cytoskeleton  hsa04810+4478  
According to Reactome, this protein belongs to the following pathway:
Recycling pathway of L1  REACT_22365  
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Moesin
GenomeRNAi: 4478
PRO: PR:P26038