DDX6 - Probable ATP-dependent RNA helicase DDX6 - human protein (Function)
 
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DDX6 »  Probable ATP-dependent RNA helicase DDX6   [ EC 3.6.4.13 ]
 
Protein also known as:  ATP-dependent RNA helicase p54.
Gene name:  DDX6
Family name: DEAD box helicase » DDX6/DHH1
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
In the process of mRNA degradation, may play a role in mRNA decapping.  
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  • UniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
1
  • UniProtKB KW
ATP-dependent RNA helicase activitydefinition[GO:0004004]  
1
  • RefGenome
Helicase activitydefinition[GO:0004386]  
2
  • PINC
Poly(A) RNA bindingdefinition[GO:0044822]  
2
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
8
  • IntAct
  • UniProtKB
Protein domain specific bindingdefinition[GO:0019904]  
1
  • BHF-UCL
RNA helicase activitydefinition[GO:0003724]  
1
  • PINC
GO biological process 
Cytoplasmic mRNA processing body assemblydefinition[GO:0033962]  
1
  • MGI
Regulation of translationdefinition[GO:0006417]  
1
  • RefGenome
RNA secondary structure unwindingdefinition[GO:0010501]  
1
  • RefGenome
Viral RNA genome packagingdefinition[GO:0019074] silver  
1
  • CACAO
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.6.4.13: ATP + H(2)O ADP + phosphate.  
1
  • UniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathway:
RNA degradation  hsa03018+1656  
According to Reactome, this protein belongs to the following pathway:
mRNA decay by 5' to 3' exoribonuclease  REACT_20518  
 

Keywords

Molecular function 
Helicase  definition   [KW-0347]
Hydrolase  definition   [KW-0378]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: DDX6
GenomeRNAi: 1656
PRO: PR:P26196