DNMT1 - DNA (cytosine-5)-methyltransferase 1 - human protein (Function)
 
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DNMT1 »  DNA (cytosine-5)-methyltransferase 1   [ EC 2.1.1.37 ]  (Dnmt1)
 
Protein also known as:  CXXC-type zinc finger protein 9.
Gene name:  DNMT1
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance. Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Mediates transcriptional repression by direct binding to HDAC2. In association with DNMT3B and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9.  
3
  • CuratedUniProtKB
GO molecular function 
Chromatin bindingdefinition[GO:0003682] silver  
  • IEAInterPro 2 GO
DNA (cytosine-5-)-methyltransferase activitydefinition[GO:0003886]  
1
  • IDAUniProtKB
DNA bindingdefinition[GO:0003677]  
1
  • IDAUniProtKB
DNA-methyltransferase activitydefinition[GO:0009008]  
1
  • IDAUniProtKB
Methyl-CpG bindingdefinition[GO:0008327] silver  
  • IEAOrtholog Compara
Protein bindingdefinition[GO:0005515]  
9
  • IPIIntAct
  • IPIUniProtKB
RNA bindingdefinition[GO:0003723] silver  
  • IEAOrtholog Compara
Transcription factor bindingdefinition[GO:0008134] silver  
  • IEAInterPro 2 GO
Zinc ion bindingdefinition[GO:0008270] silver  
  • IEAOrtholog Compara
GO biological process 
Cellular response to amino acid stimulusdefinition[GO:0071230] silver  
  • IEAOrtholog Compara
Chromatin modificationdefinition[GO:0016568]  
  • IEAUniProtKB KW
DNA methylationdefinition[GO:0006306]  
1
  • TASPINC
Gene silencingdefinition[GO:0016458] silver  
  • IEAOrtholog Compara
Maintenance of DNA methylationdefinition[GO:0010216]  
2
  • IDAUniProtKB
Negative regulation of histone H3-K9 methylationdefinition[GO:0051573]  
1
  • IMPUniProtKB
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122] silver  
  • IEAOrtholog Compara
Positive regulation of gene expressiondefinition[GO:0010628]  
1
  • IMPUniProtKB
Positive regulation of histone H3-K4 methylationdefinition[GO:0051571]  
1
  • IMPUniProtKB
Regulation of cell proliferationdefinition[GO:0042127] silver  
  • IEAOrtholog Compara
Transcription, DNA-templateddefinition[GO:0006351]  
  • IEAUniProtKB KW
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.1.1.37: S-adenosyl-L-methionine + DNA S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine.  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Cysteine and methionine metabolism  hsa00270+1786  
Metabolic pathways  hsa01100+1786  
According to Reactome, this protein belongs to the following pathway:
Gene Expression  REACT_71  
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Activator  definition   [KW-0010]
Chromatin regulator  definition   [KW-0156]
Methyltransferase  definition   [KW-0489]
Repressor  definition   [KW-0678]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: DNMT1
GenomeRNAi: 1786
PRO: PR:P26358