HSD3B2 - 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2 - human protein (Function)
 
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HSD3B2 »  3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2
 
Protein also known as:  3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II (3-beta-HSD II).
Gene name:  HSD3B2
Family name: 3-beta-HSD
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 68 2
GENE REF ISO

Function

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Overview 
3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids.  
  • CuratedUniProtKB
GO molecular function 
3-beta-hydroxy-delta5-steroid dehydrogenase activitydefinition[GO:0003854]  
1
  • IDAUniProtKB
Steroid delta-isomerase activitydefinition[GO:0004769]  
1
  • IDAUniProtKB
GO biological process 
Steroid biosynthetic processdefinition[GO:0006694]  
1
  • IDAUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reactions
EC 1.1.1.145: A 3-beta-hydroxy-Delta(5)-steroid + NAD(+) a 3-oxo-Delta(5)-steroid + NADH.  
  • CuratedUniProtKB
EC 5.3.3.1: A 3-oxo-Delta(5)-steroid a 3-oxo-Delta(4)-steroid.  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
This protein is involved in the following pathway
  • CuratedUniProtKB
According to KEGG, this protein belongs to the following pathways:
Metabolic pathways  hsa01100+3284  
Steroid hormone biosynthesis  hsa00140+3284  
According to Reactome, this protein belongs to the following pathways:
Metabolism  REACT_111217  
Steroid hormones  REACT_15493  
 
More information is available from:
 

Keywords

Biological process 
Steroidogenesis  definition   [KW-0755]
Molecular function 
Isomerase  definition   [KW-0413]
Oxidoreductase  definition   [KW-0560]
Technical term 
Multifunctional enzyme  definition   [KW-0511]
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: HSD3B2
GenomeRNAi: 3284
PRO: PR:P26439