IVD - Isovaleryl-CoA dehydrogenase, mitochondrial - human protein (Function)
 
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Protein
Gene
References

 
IVD »  Isovaleryl-CoA dehydrogenase, mitochondrial   [ EC 1.3.8.4 ]  (IVD)
 
Gene name:  IVD
Family name: Acyl-CoA dehydrogenase
Entry whose protein(s) existence is based on evidence at protein level
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1 33 2
GENE REF ISO

Function

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GO molecular function 
Flavin adenine dinucleotide bindingdefinition[GO:0050660] silver  
  • IEAInterPro 2 GO
Isovaleryl-CoA dehydrogenase activitydefinition[GO:0008470]  
  • ISSOrtholog Curator
GO biological process 
Leucine catabolic processdefinition[GO:0006552]  
  • ISSOrtholog Curator
  • IEAUniPathway
Oxidation-reduction processdefinition[GO:0055114]  
  • IEAUniProtKB KW
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 1.3.8.4: Isovaleryl-CoA + electron-transfer flavoprotein 3-methylcrotonyl-CoA + reduced electron-transfer flavoprotein.  
  • CuratedUniProtKB
It requires the following cofactor
FAD.  
  • CuratedUniProtKB
Pathways 
This protein is involved in the following pathway
According to KEGG, this protein belongs to the following pathways:
Metabolic pathways  hsa01100+3712  
Valine, leucine and isoleucine degradation  hsa00280+3712  
According to Reactome, this protein belongs to the following pathway:
Branched-chain amino acid catabolism  REACT_197  
 

Keywords

Molecular function 
Oxidoreductase  definition   [KW-0560]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: P26440
Other
GenomeRNAi: 3712
PRO: PR:P26440