PLN - Cardiac phospholamban - human protein (Function)
 
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PLN »  Cardiac phospholamban  (PLB)
 
Gene name:  PLN
Family name: Phospholamban
Entry whose protein(s) existence is based on evidence at protein level
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1 87 1
GENE REF ISO

Function

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Overview 
Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. ATP2A2 inhibition is alleviated by PLN phosphorylation.  
3
  • UniProtKB
According to TCDB this is a transporter from family:
the phospholamban (ca(2+)-channel and ca(2+)-atpase regulator) (plb) family  1.A.50.1.1  
GO molecular function 
ATPase bindingdefinition[GO:0051117]  
1
  • BHF-UCL
ATPase inhibitor activitydefinition[GO:0042030]  
2
  • BHF-UCL
  • Ortholog Curator
Calcium channel regulator activitydefinition[GO:0005246] silver  
1
  • InterPro 2 GO
Enzyme inhibitor activitydefinition[GO:0004857]  
1
  • BHF-UCL
Identical protein bindingdefinition[GO:0042802]  
1
  • Ortholog Curator
Protein bindingdefinition[GO:0005515]  
2
  • IntAct
GO biological process 
Adrenergic receptor signaling pathway involved in heart processdefinition[GO:0086023] silver  
1
  • Ortholog Compara
Blood circulationdefinition[GO:0008015]  
1
  • PINC
Calcium ion transportdefinition[GO:0006816] silver  
1
  • InterPro 2 GO
Cardiac muscle tissue developmentdefinition[GO:0048738] silver  
1
  • Ortholog Compara
Cytosolic calcium ion homeostasisdefinition[GO:0051480]  
1
  • BHF-UCL
Negative regulation of ATPase activitydefinition[GO:0032780]  
2
  • BHF-UCL
  • Ortholog Curator
Negative regulation of calcium ion bindingdefinition[GO:1901877]  
3
  • BHF-UCL
  • Ortholog Curator
Negative regulation of calcium ion importdefinition[GO:0090281]  
1
  • BHF-UCL
Negative regulation of calcium ion import into sarcoplasmic reticulumdefinition[GO:1902081]  
1
  • Ortholog Curator
Negative regulation of calcium ion transmembrane transporter activitydefinition[GO:1901020]  
3
  • BHF-UCL
  • Ortholog Curator
Negative regulation of calcium ion transportdefinition[GO:0051926]  
1
  • BHF-UCL
Negative regulation of calcium-transporting ATPase activitydefinition[GO:1901895]  
1
  • BHF-UCL
Negative regulation of catalytic activitydefinition[GO:0043086]  
1
  • BHF-UCL
Negative regulation of heart ratedefinition[GO:0010459]  
1
  • BHF-UCL
Protein homooligomerizationdefinition[GO:0051260] silver  
1
  • Ortholog Compara
Regulation of calcium ion transportdefinition[GO:0051924]  
2
  • UniProtKB
  • Ortholog Curator
Regulation of calcium-transporting ATPase activitydefinition[GO:1901894]  
1
  • UniProtKB
Regulation of cardiac muscle cell contractiondefinition[GO:0086004]  
1
  • BHF-UCL
Regulation of cardiac muscle cell membrane potentialdefinition[GO:0086036]  
1
  • BHF-UCL
Regulation of cardiac muscle contraction by regulation of the release of sequestered calcium iondefinition[GO:0010881] silver  
1
  • Ortholog Compara
Regulation of heart contractiondefinition[GO:0008016]  
1
  • BHF-UCL
Regulation of relaxation of cardiac muscledefinition[GO:1901897]  
1
  • BHF-UCL
Regulation of ryanodine-sensitive calcium-release channel activitydefinition[GO:0060314] silver  
1
  • Ortholog Compara
Regulation of the force of heart contractiondefinition[GO:0002026]  
1
  • BHF-UCL
Regulation of the force of heart contraction by cardiac conductiondefinition[GO:0086092] silver  
1
  • Ortholog Compara
Relaxation of cardiac muscledefinition[GO:0055119]  
1
  • BHF-UCL
Response to insulindefinition[GO:0032868] silver  
1
  • Ortholog Compara
Response to testosteronedefinition[GO:0033574] silver  
1
  • Ortholog Compara
Response to zinc iondefinition[GO:0010043] silver  
1
  • Ortholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathways:
Calcium signaling pathway  hsa04020+5350  
Dilated cardiomyopathy  hsa05414+5350  
According to Reactome, this protein belongs to the following pathway:
Ion transport by P-type ATPases  REACT_25149  
Note 
For practical reasons, PLN activity is most often studied with ATP2A1 instead of ATP2A2.  
1
  • UniProtKB
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Phospholamban
GenomeRNAi: 5350
PRO: PR:P26678