CD27 - CD27 antigen - human protein (Function)
 
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Protein
Gene
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CD27 »  CD27 antigen
 
Protein also known as:  Tumor necrosis factor receptor superfamily member 7; CD antigen CD27.
Gene name:  CD27
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Receptor for CD70/CD27L. May play a role in survival of activated T-cells. May play a role in apoptosis through association with SIVA1.  
1
  • UniProtKB
GO molecular function 
Cysteine-type endopeptidase inhibitor activity involved in apoptotic processdefinition[GO:0043027]  
1
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
3
  • HGNC
  • UniProtKB
  • IntAct
Transmembrane signaling receptor activitydefinition[GO:0004888]  
1
  • UniProtKB
Tumor necrosis factor-activated receptor activitydefinition[GO:0005031]  
1
  • RefGenome
GO biological process 
Brain developmentdefinition[GO:0007420]  
1
  • RefGenome
Cell surface receptor signaling pathwaydefinition[GO:0007166]  
1
  • UniProtKB
Extrinsic apoptotic signaling pathwaydefinition[GO:0097191]  
1
  • BHF-UCL
Extrinsic apoptotic signaling pathway via death domain receptorsdefinition[GO:0008625]  
1
  • RefGenome
Immune responsedefinition[GO:0006955]  
1
  • RefGenome
Immunoglobulin mediated immune responsedefinition[GO:0016064]  
1
  • UniProtKB
Inflammatory responsedefinition[GO:0006954]  
1
  • RefGenome
Negative regulation of apoptotic processdefinition[GO:0043066]  
1
  • UniProtKB
Negative regulation of cysteine-type endopeptidase activity involved in apoptotic processdefinition[GO:0043154]  
1
  • GOC
Negative regulation of T cell apoptotic processdefinition[GO:0070233] silver  
1
  • Ortholog Compara
Positive regulation of B cell differentiationdefinition[GO:0045579]  
1
  • UniProtKB
Positive regulation of JNK cascadedefinition[GO:0046330]  
1
  • Ortholog Curator
Positive regulation of MAPK cascadedefinition[GO:0043410]  
1
  • RefGenome
Regulation of cell proliferationdefinition[GO:0042127]  
1
  • RefGenome
Release of cytoplasmic sequestered NF-kappaBdefinition[GO:0008588]  
1
  • UniProtKB
Response to ethanoldefinition[GO:0045471] silver  
1
  • Ortholog Compara
Response to lipopolysaccharidedefinition[GO:0032496]  
1
  • RefGenome
Pathways 
According to KEGG, this protein belongs to the following pathway:
Cytokine-cytokine receptor interaction  hsa04060+939  
According to Reactome, this protein belongs to the following pathway:
TNFs bind their physiological receptors  R-HSA-5669034  
 

Keywords

Biological process 
Apoptosis  definition   [KW-0053]
Molecular function 
Receptor  definition   [KW-0675]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: CD27
GenomeRNAi: 939
PRO: PR:P26842
Chemistry
GuidetoPHARMACOLOGY: 1876