FKBP2 - Peptidyl-prolyl cis-trans isomerase FKBP2 - human protein (Function)
 
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FKBP2 »  Peptidyl-prolyl cis-trans isomerase FKBP2   [ EC 5.2.1.8 ]  (PPIase FKBP2)
 
Protein also known as:  13 kDa FK506-binding protein (FKBP-13).
Gene name:  FKBP2
Family name: FKBP-type PPIase » FKBP2
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.  
  • CuratedUniProtKB
GO molecular function 
FK506 bindingdefinition[GO:0005528] silver  
  • IBARefGenome
Peptidyl-prolyl cis-trans isomerase activitydefinition[GO:0003755] silver  
  • IBARefGenome
Protein bindingdefinition[GO:0005515]  
1
  • IPIIntAct
GO biological process 
Peptidyl-proline modificationdefinition[GO:0018208] silver  
  • IBARefGenome
Protein foldingdefinition[GO:0006457]  
  • IEAUniProtKB KW
Protein peptidyl-prolyl isomerizationdefinition[GO:0000413] silver  
  • IBARefGenome
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 5.2.1.8: Peptidylproline (omega180) peptidylproline (omega0).  
  • CuratedUniProtKB
It is regulated in the following manner
Inhibited by both FK506 and rapamycin.  
  • CuratedUniProtKB
 

Keywords

Molecular function 
Isomerase  definition   [KW-0413]
Rotamase  definition   [KW-0697]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: FKBP2
GenomeRNAi: 2286
PRO: PR:P26885