ACVR2A - Activin receptor type-2A - human protein (Function)
 
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ACVR2A »  Activin receptor type-2A   [ EC 2.7.11.30 ]
 
Protein also known as:  Activin receptor type IIA (ACTRIIA).
Gene name:  ACVR2A
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 58 2
GENE REF ISO

Function

 show evidences
Overview 
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A.  
  • CuratedUniProtKB
GO molecular function 
Contributes to activin bindingdefinition[GO:0048185]  
1
  • IPIHGNC
Contributes to activin-activated receptor activitydefinition[GO:0017002]  
1
  • IDAHGNC
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Coreceptor activitydefinition[GO:0015026]  
1
  • IDABHF-UCL
Growth factor bindingdefinition[GO:0019838] silver  
  • IEAOrtholog Compara
Inhibin bindingdefinition[GO:0034711] silver  
  • IEAOrtholog Compara
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
PDZ domain bindingdefinition[GO:0030165] silver  
  • IEAOrtholog Compara
Contributes to protein bindingdefinition[GO:0005515]  
6
  • IPIUniProtKB
  • IPIBHF-UCL
  • IPIHGNC
Protein self-associationdefinition[GO:0043621] silver  
  • IEAOrtholog Compara
Receptor signaling protein serine/threonine kinase activitydefinition[GO:0004702] silver  
  • IEAInterPro 2 GO
Transforming growth factor beta-activated receptor activitydefinition[GO:0005024] silver  
  • IEAInterPro 2 GO
Transmembrane receptor protein serine/threonine kinase activitydefinition[GO:0004675]  
1
  • TASPINC
GO biological process 
Activin receptor signaling pathwaydefinition[GO:0032924]  
1
  • IDAGOC
Anterior/posterior pattern specificationdefinition[GO:0009952] silver  
  • IEAOrtholog Compara
BMP signaling pathwaydefinition[GO:0030509]  
3
  • IMPBHF-UCL
  • IMPMGI
Determination of left/right symmetrydefinition[GO:0007368] silver  
  • IEAOrtholog Compara
Embryonic skeletal system developmentdefinition[GO:0048706] silver  
  • IEAOrtholog Compara
Gastrulation with mouth forming seconddefinition[GO:0001702] silver  
  • IEAOrtholog Compara
Mesoderm developmentdefinition[GO:0007498] silver  
  • IEAOrtholog Compara
Penile erectiondefinition[GO:0043084] silver  
  • IEAOrtholog Compara
Positive regulation of activin receptor signaling pathwaydefinition[GO:0032927]  
1
  • IDAHGNC
Positive regulation of bone mineralizationdefinition[GO:0030501]  
1
  • IMPBHF-UCL
Positive regulation of erythrocyte differentiationdefinition[GO:0045648]  
1
  • IDAHGNC
Positive regulation of osteoblast differentiationdefinition[GO:0045669]  
1
  • IMPBHF-UCL
Positive regulation of pathway-restricted SMAD protein phosphorylationdefinition[GO:0010862]  
1
  • IMPBHF-UCL
Positive regulation of protein phosphorylationdefinition[GO:0001934]  
1
  • IMPMGI
Regulation of BMP signaling pathwaydefinition[GO:0030510] silver  
  • IEAOrtholog Compara
Regulation of nitric-oxide synthase activitydefinition[GO:0050999] silver  
  • IEAOrtholog Compara
Sertoli cell proliferationdefinition[GO:0060011] silver  
  • IEAOrtholog Compara
Sperm ejaculationdefinition[GO:0042713] silver  
  • IEAOrtholog Compara
Spermatogenesisdefinition[GO:0007283] silver  
  • IEAOrtholog Compara
Transmembrane receptor protein serine/threonine kinase signaling pathwaydefinition[GO:0007178]  
1
  • TASPINC
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.11.30: ATP + [receptor-protein] ADP + [receptor-protein] phosphate.  
  • CuratedUniProtKB
It requires the following cofactor
Magnesium or manganese (By similarity).  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Cytokine-cytokine receptor interaction  hsa04060+92  
TGF-beta signaling pathway  hsa04350+92  
According to Reactome, this protein belongs to the following pathways:
Developmental Biology  REACT_111045  
Signal Transduction  REACT_111102  
 

Keywords

Molecular function 
Kinase  definition   [KW-0418]
Receptor  definition   [KW-0675]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: ACVR2A
GenomeRNAi: 92
PRO: PR:P27037
Chemistry
GuidetoPHARMACOLOGY: 1791