AK4 - Adenylate kinase 4, mitochondrial - human protein (Function)
 
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AK4 »  Adenylate kinase 4, mitochondrial   [ EC 2.7.4.10EC 2.7.4.6 ]  (AK 4)
 
Protein also known as:  GTP:AMP phosphotransferase AK4.
Gene name:  AK4
Family name: Adenylate kinase » AK3
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Efficiently phosphorylates AMP and dAMP using ATP as phosphate donor, but phosphorylates only AMP when using GTP as phosphate donor. Also displays broad nucleoside diphosphate kinase activity.  
3
  • CuratedUniProtKB
GO molecular function 
Contradiction  Adenylate kinase activitydefinition[GO:0004017]  
2
  • IDABHF-UCL
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
GTP bindingdefinition[GO:0005525]  
  • IEAUniProtKB KW
Nucleoside diphosphate kinase activitydefinition[GO:0004550]  
1
  • IDAUniProtKB
Contradiction  Nucleoside triphosphate adenylate kinase activitydefinition[GO:0046899]  
2
  • IDABHF-UCL
GO biological process 
AMP metabolic processdefinition[GO:0046033]  
1
  • IDABHF-UCL
ATP metabolic processdefinition[GO:0046034]  
1
  • IDABHF-UCL
Brain developmentdefinition[GO:0007420] silver  
  • IEAOrtholog Compara
GTP metabolic processdefinition[GO:0046039]  
1
  • IDABHF-UCL
Liver developmentdefinition[GO:0001889] silver  
  • IEAOrtholog Compara
Nucleoside diphosphate phosphorylationdefinition[GO:0006165]  
1
  • IDAUniProtKB
Nucleoside triphosphate biosynthetic processdefinition[GO:0009142]  
1
  • IDAUniProtKB
Response to drugdefinition[GO:0042493] silver  
  • IEAOrtholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reactions
EC 2.7.4.10: NTP + AMP NDP + ADP.  
2
  • CuratedUniProtKB
EC 2.7.4.6: ATP + nucleoside diphosphate ADP + nucleoside triphosphate.  
2
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Metabolic pathways  hsa01100+205  
Purine metabolism  hsa00230+205  
 

Biophysicochemical properties

Kinetic parameters
KM 507 uM for dAMP with ATP as phosphate donor
KM 1.4 uM for AMP with GTP as phosphate donor
KM 5.3 uM for AMP with ATP as phosphate donor
Vmax 88 pmol/min/ug enzyme with dAMP as substrate and ATP as phosphate donor
Vmax 90 pmol/min/ug enzyme with AMP as substrate and ATP as phosphate donor
Vmax 80 pmol/min/ug enzyme with AMP as substrate and GTP as phosphate donor

Keywords

Molecular function 
Kinase  definition   [KW-0418]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: AK3L1
PRO: PR:P27144