YWHAQ - 14-3-3 protein theta - human protein (Function)
 
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YWHAQ »  14-3-3 protein theta
 
Protein also known as:  14-3-3 protein T-cell.
Gene name:  YWHAQ
Family name: 14-3-3
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1.  
1
  • CuratedUniProtKB
GO molecular function 
Protein bindingdefinition[GO:0005515]  
26
  • IPIIntAct
  • IPIUniProtKB
Protein domain specific bindingdefinition[GO:0019904] silver  
  • IEAOrtholog Compara
Protein N-terminus bindingdefinition[GO:0047485]  
1
  • IPIUniProtKB
GO biological process 
Negative regulation of transcription, DNA-templateddefinition[GO:0045892]  
1
  • IDABHF-UCL
Protein targetingdefinition[GO:0006605] silver  
  • IEAOrtholog Compara
Small GTPase mediated signal transductiondefinition[GO:0007264] silver  
  • IEAOrtholog Compara
Substantia nigra developmentdefinition[GO:0021762]  
1
  • IEPUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Cell cycle  hsa04110+10971  
Neurotrophin signaling pathway  hsa04722+10971  
Oocyte meiosis  hsa04114+10971  
Pathogenic Escherichia coli infection  hsa05130+10971  
According to Reactome, this protein belongs to the following pathway:
Translocation of GLUT4 to the plasma membrane  REACT_147867  
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: YWHAQ
GenomeRNAi: 10971
PRO: PR:P27348