MARK3 - MAP/microtubule affinity-regulating kinase 3 - human protein (Function)
 
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MARK3 »  MAP/microtubule affinity-regulating kinase 3   [ EC 2.7.11.1 ]
 
Protein also known as:  Serine/threonine-protein kinase p78.
Gene name:  MARK3
Entry whose protein(s) existence is based on evidence at protein level
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1 109 7
GENE REF ISO

Function

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Overview 
Involved in the specific phosphorylation of microtubule-associated proteins for tau, MAP2 and MAP4. Phosphorylates CDC25C on 'Ser-216'. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus.  
1
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Protein bindingdefinition[GO:0005515]  
10
  • IPIIntAct
  • IPIUniProtKB
Protein serine/threonine kinase activitydefinition[GO:0004674]  
1
  • IDAUniProtKB
GO biological process 
Protein phosphorylationdefinition[GO:0006468] silver  
  • IEAInterPro 2 GO
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.11.1: ATP + a protein ADP + a phosphoprotein.  
  • CuratedUniProtKB
It is regulated in the following manner
Activated by phosphorylation on Thr-211. Inhibited by phosphorylation on Thr-564.  
1
  • CuratedUniProtKB
 

Keywords

Molecular function 
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: MARK3
GenomeRNAi: 4140
PRO: PR:P27448
Chemistry
GuidetoPHARMACOLOGY: 2099