DPP4 - Dipeptidyl peptidase 4 - human protein (Function)
 
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DPP4 »  Dipeptidyl peptidase 4   [ EC 3.4.14.5 ]
 
Protein also known as:  Adenosine deaminase complexing protein 2 (ADCP-2); CD antigen CD26. Cleaved into:  Dipeptidyl peptidase 4 membrane form; Dipeptidyl peptidase 4 soluble form.
Gene name:  DPP4
Family name: Peptidase S9B » DPPIV
Entry whose protein(s) existence is based on evidence at protein level
extend overview
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GENE REF ISO

Function

 show evidences
Overview 
Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM. May be involved in the promotion of lymphatic endothelial cells adhesion, migration and tube formation. When overexpressed, enhanced cell proliferation, a process inhibited by GPC3. Acts also as a serine exopeptidase with a dipeptidyl peptidase activity that regulates various physiological processes by cleaving peptides in the circulation, including many chemokines, mitogenic growth factors, neuropeptides and peptide hormones. Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.  
9
  • CuratedUniProtKB
GO molecular function 
Dipeptidyl-peptidase activitydefinition[GO:0008239]  
3
  • IDAUniProtKB
Identical protein bindingdefinition[GO:0042802]  
1
  • IPIIntAct
Protease bindingdefinition[GO:0002020]  
1
  • IPIUniProtKB
Protein bindingdefinition[GO:0005515]  
8
  • IPIIntAct
  • IPIUniProtKB
Protein homodimerization activitydefinition[GO:0042803]  
2
  • IPIUniProtKB
Receptor bindingdefinition[GO:0005102]  
1
  • IPIUniProtKB
Serine-type endopeptidase activitydefinition[GO:0004252] silver  
  • IEAInterPro 2 GO
Serine-type peptidase activitydefinition[GO:0008236]  
1
  • IDAUniProtKB
GO biological process 
Cell adhesiondefinition[GO:0007155]  
  • IEAUniProtKB KW
Endothelial cell migrationdefinition[GO:0043542]  
1
  • IDAUniProtKB
Negative regulation of extracellular matrix disassemblydefinition[GO:0010716]  
1
  • IDAUniProtKB
Positive regulation of cell proliferationdefinition[GO:0008284]  
1
  • IDAUniProtKB
Proteolysisdefinition[GO:0006508]  
  • IEAUniProtKB KW
Regulation of cell-cell adhesion mediated by integrindefinition[GO:0033632]  
1
  • IDAUniProtKB
Response to hypoxiadefinition[GO:0001666]  
1
  • IDAUniProtKB
T cell activationdefinition[GO:0042110]  
1
  • IDAUniProtKB
T cell costimulationdefinition[GO:0031295]  
2
  • IDAUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.4.14.5: Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.  
  • CuratedUniProtKB
It is regulated in the following manner
Inhibited by GPC3 and diprotin A.  
2
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathway:
Protein digestion and absorption  hsa04974+1803  
According to Reactome, this protein belongs to the following pathways:
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)  REACT_24019  
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)  REACT_23824  
Note 
Level of plasma concentrations of the soluble form (SDPP) can be managed as a colon carcinoma diagnostic and prognostic marker.  
  • CuratedUniProtKB
 

Keywords

Biological process 
Cell adhesion  definition   [KW-0130]
Molecular function 
Aminopeptidase  definition   [KW-0031]
Hydrolase  definition   [KW-0378]
Protease  definition   [KW-0645]
Receptor  definition   [KW-0675]
Serine protease  definition   [KW-0720]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: P27487
Other
GeneWiki: Dipeptidyl_peptidase-4
GenomeRNAi: 1803
PRO: PR:P27487
Chemistry
GuidetoPHARMACOLOGY: 1612