DPP4 - Dipeptidyl peptidase 4 - human protein (Function)
 
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Protein
Gene
References

 
DPP4 »  Dipeptidyl peptidase 4   [ EC 3.4.14.5 ]
 
Protein also known as:  Adenosine deaminase complexing protein 2 (ADCP-2); CD antigen CD26. Cleaved into:  Dipeptidyl peptidase 4 membrane form; Dipeptidyl peptidase 4 soluble form.
Gene name:  DPP4
Family name: Peptidase S9B » DPPIV
Entry whose protein(s) existence is based on evidence at protein level
extend overview
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GENE REF ISO

Function

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Overview 
Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM. May be involved in the promotion of lymphatic endothelial cells adhesion, migration and tube formation. When overexpressed, enhanced cell proliferation, a process inhibited by GPC3. Acts also as a serine exopeptidase with a dipeptidyl peptidase activity that regulates various physiological processes by cleaving peptides in the circulation, including many chemokines, mitogenic growth factors, neuropeptides and peptide hormones. Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.  
11
  • UniProtKB
GO molecular function 
Dipeptidyl-peptidase activitydefinition[GO:0008239]  
4
  • UniProtKB
Identical protein bindingdefinition[GO:0042802]  
1
  • IntAct
Protease bindingdefinition[GO:0002020]  
1
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
8
  • IntAct
  • UniProtKB
Protein homodimerization activitydefinition[GO:0042803]  
2
  • UniProtKB
Receptor bindingdefinition[GO:0005102]  
1
  • UniProtKB
Serine-type endopeptidase activitydefinition[GO:0004252] silver  
1
  • InterPro 2 GO
Serine-type peptidase activitydefinition[GO:0008236]  
1
  • UniProtKB
Virus receptor activitydefinition[GO:0001618] silver  
1
  • CACAO
GO biological process 
Endothelial cell migrationdefinition[GO:0043542]  
1
  • UniProtKB
Negative regulation of extracellular matrix disassemblydefinition[GO:0010716]  
1
  • UniProtKB
Positive regulation of cell proliferationdefinition[GO:0008284]  
1
  • UniProtKB
Proteolysisdefinition[GO:0006508]  
1
  • UniProtKB KW
Regulation of cell-cell adhesion mediated by integrindefinition[GO:0033632]  
1
  • UniProtKB
Response to hypoxiadefinition[GO:0001666]  
1
  • UniProtKB
T cell activationdefinition[GO:0042110]  
1
  • UniProtKB
T cell costimulationdefinition[GO:0031295]  
2
  • UniProtKB
Viral entry into host celldefinition[GO:0046718]  
1
  • GOC
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.4.14.5: Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.  
3
  • UniProtKB
  • PROSITE-ProRule
It is regulated in the following manner
Inhibited by GPC3 and diprotin A.  
3
  • UniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathway:
Protein digestion and absorption  hsa04974+1803  
According to Reactome, this protein belongs to the following pathways:
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)  REACT_24019  
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)  REACT_23824  
Note 
Level of plasma concentrations of the soluble form (SDPP) can be managed as a colon carcinoma diagnostic and prognostic marker.  
1
  • UniProtKB
 

Keywords

Biological process 
Cell adhesion  definition   [KW-0130]
Molecular function 
Aminopeptidase  definition   [KW-0031]
Hydrolase  definition   [KW-0378]
Protease  definition   [KW-0645]
Receptor  definition   [KW-0675]
Serine protease  definition   [KW-0720]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: P27487
Other
GeneWiki: Dipeptidyl_peptidase-4
GenomeRNAi: 1803
PRO: PR:P27487
Chemistry
GuidetoPHARMACOLOGY: 1612