ARNT - Aryl hydrocarbon receptor nuclear translocator - human protein (Function)
 
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Protein
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ARNT »  Aryl hydrocarbon receptor nuclear translocator
 
Gene name:  ARNT
Entry whose protein(s) existence is based on evidence at protein level
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1 65 4
GENE REF ISO

Function

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Overview 
Required for activity of the Ah (dioxin) receptor. This protein is required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding. The complex then initiates transcription of genes involved in the activation of PAH procarcinogens. The heterodimer with HIF1A or EPAS1/HIF2A functions as a transcriptional regulator of the adaptive response to hypoxia.  
  • CuratedUniProtKB
GO molecular function 
Aryl hydrocarbon receptor activitydefinition[GO:0004874] silver  
  • IEAOrtholog Compara
Aryl hydrocarbon receptor bindingdefinition[GO:0017162]  
1
  • IPIBHF-UCL
Enhancer bindingdefinition[GO:0035326]  
1
  • IDAMGI
Protein bindingdefinition[GO:0005515]  
7
  • IPIIntAct
Protein heterodimerization activitydefinition[GO:0046982]  
1
  • IPIBHF-UCL
Contributes to RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activitydefinition[GO:0003705]  
2
  • IDABHF-UCL
Contributes to sequence-specific DNA bindingdefinition[GO:0043565]  
1
  • IDABHF-UCL
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700]  
2
  • TASPINC
Transcription coactivator activitydefinition[GO:0003713] silver  
  • IEAOrtholog Compara
Transcription factor bindingdefinition[GO:0008134]  
3
  • IPIBHF-UCL
GO biological process 
Cell differentiationdefinition[GO:0030154] silver  
  • IEAOrtholog Compara
Embryonic placenta developmentdefinition[GO:0001892] silver  
  • IEAOrtholog Compara
Intracellular receptor signaling pathwaydefinition[GO:0030522] silver  
  • IEAOrtholog Compara
mRNA transcription from RNA polymerase II promoterdefinition[GO:0042789]  
1
  • ICBHF-UCL
Positive regulation of endothelial cell proliferationdefinition[GO:0001938]  
1
  • ICBHF-UCL
Positive regulation of erythrocyte differentiationdefinition[GO:0045648]  
1
  • ICBHF-UCL
Positive regulation of glycolytic processdefinition[GO:0045821]  
1
  • ICBHF-UCL
Positive regulation of hormone biosynthetic processdefinition[GO:0046886]  
1
  • IDABHF-UCL
Positive regulation of protein sumoylationdefinition[GO:0033235] silver  
  • IEAOrtholog Compara
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944] silver  
  • IEAOrtholog Compara
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
1
  • IDABHF-UCL
Positive regulation of vascular endothelial growth factor receptor signaling pathwaydefinition[GO:0030949]  
1
  • ICBHF-UCL
Positive regulation vascular endothelial growth factor productiondefinition[GO:0010575]  
1
  • IDABHF-UCL
Regulation of transcription from RNA polymerase II promoter in response to oxidative stressdefinition[GO:0043619]  
1
  • IDABHF-UCL
Response to hypoxiadefinition[GO:0001666]  
1
  • IDABHF-UCL
Transcription, DNA-templateddefinition[GO:0006351]  
1
  • TASPINC
Pathways 
According to KEGG, this protein belongs to the following pathways:
Pathways in cancer  hsa05200+405  
Renal cell carcinoma  hsa05211+405  
According to Reactome, this protein belongs to the following pathway:
Regulation of gene expression by Hypoxia-inducible Factor  REACT_121092  
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Activator  definition   [KW-0010]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links