CERS1 - Ceramide synthase 1 - human protein (Function)
 
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Protein
Gene
References

 
CERS1 »  Ceramide synthase 1  (CerS1)
 
Protein also known as:  Longevity assurance gene 1 protein homolog 1.
Gene name:  CERS1
Entry whose protein(s) existence is based on evidence at protein level
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1 19 2
GENE REF ISO

Function

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Overview 
May be either a bona fide (dihydro)ceramide synthase or a modulator of its activity. When overexpressed in cells is involved in the production of sphingolipids containing mainly one fatty acid donor (N-linked stearoyl- (C18) ceramide) in a fumonisin B1-independent manner (By similarity).  
  • CuratedUniProtKB
GO molecular function 
Sphingosine N-acyltransferase activitydefinition[GO:0050291]  
  • ISSOrtholog Curator
GO biological process 
Cellular response to dithiothreitoldefinition[GO:0072721]  
1
  • IDAUniProtKB
Cellular response to drugdefinition[GO:0035690]  
1
  • IDAUniProtKB
Cellular response to mycotoxindefinition[GO:0036146]  
1
  • IDAUniProtKB
Cellular response to UV-Adefinition[GO:0071492]  
1
  • IDAUniProtKB
Ceramide biosynthetic processdefinition[GO:0046513]  
5
  • IDAUniProtKB
  • ISSOrtholog Curator
Negative regulation of telomerase activitydefinition[GO:0051974]  
1
  • IDAUniProtKB
Sphingolipid biosynthetic processdefinition[GO:0030148]  
1
  • IDAUniProtKB
Pathways 
According to Reactome, this protein belongs to the following pathway:
Sphingolipid de novo biosynthesis  REACT_115810  
 
More information is available from:
Note 
This protein is produced by a bicistronic gene which also produces the GDF1 protein from a non-overlapping reading frame.  
  • CuratedUniProtKB
 

Keywords

Biological process 
Lipid biosynthesis  definition   [KW-0444]
Lipid metabolism  definition   [KW-0443]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: LASS1
GenomeRNAi: 10715
PRO: PR:P27544