CALR - Calreticulin - human protein (Function)
 
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CALR »  Calreticulin
 
Protein also known as:  Endoplasmic reticulum resident protein 60 (ERp60).
Gene name:  CALR
Family name: Calreticulin
Entry whose protein(s) existence is based on evidence at protein level
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1 164 1
GENE REF ISO

Function

 show evidences
Overview 
Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export. Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis (By similarity).  
2
  • CuratedUniProtKB
GO molecular function 
Androgen receptor bindingdefinition[GO:0050681]  
1
  • IDABHF-UCL
Calcium ion bindingdefinition[GO:0005509]  
2
  • TASUniProtKB
  • ISSOrtholog Curator
Carbohydrate bindingdefinition[GO:0030246]  
1
  • TASBHF-UCL
Chaperone bindingdefinition[GO:0051087]  
1
  • TASBHF-UCL
Complement component C1q bindingdefinition[GO:0001849]  
1
  • TASBHF-UCL
DNA bindingdefinition[GO:0003677]  
1
  • NASUniProtKB
Glycoprotein bindingdefinition[GO:0001948] silver  
  • IEAOrtholog Compara
Hormone bindingdefinition[GO:0042562] silver  
  • IEAOrtholog Compara
Integrin bindingdefinition[GO:0005178]  
1
  • IPIBHF-UCL
Iron ion bindingdefinition[GO:0005506] silver  
  • IEAOrtholog Compara
mRNA bindingdefinition[GO:0003729]  
1
  • IDABHF-UCL
Peptide bindingdefinition[GO:0042277] silver  
  • IEAOrtholog Compara
Poly(A) RNA bindingdefinition[GO:0044822]  
1
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
1
  • IPIIntAct
Protein binding involved in protein foldingdefinition[GO:0044183]  
1
  • TASBHF-UCL
Ubiquitin protein ligase bindingdefinition[GO:0031625]  
1
  • IPIUniProtKB
Unfolded protein bindingdefinition[GO:0051082]  
1
  • TASBHF-UCL
Zinc ion bindingdefinition[GO:0008270]  
1
  • TASBHF-UCL
GO biological process 
Cardiac muscle cell differentiationdefinition[GO:0055007] silver  
  • IEAOrtholog Compara
Cell cycle arrestdefinition[GO:0007050]  
1
  • IGIBHF-UCL
Cellular calcium ion homeostasisdefinition[GO:0006874]  
1
  • TASUniProtKB
Cellular response to lithium iondefinition[GO:0071285] silver  
  • IEAOrtholog Compara
Cellular senescencedefinition[GO:0090398]  
1
  • IGIBHF-UCL
Chaperone-mediated protein foldingdefinition[GO:0061077] silver  
  • IEAOrtholog Compara
Cortical actin cytoskeleton organizationdefinition[GO:0030866] silver  
  • IEAOrtholog Compara
Glucocorticoid receptor signaling pathwaydefinition[GO:0042921]  
1
  • TASBHF-UCL
Negative regulation of intracellular steroid hormone receptor signaling pathwaydefinition[GO:0033144]  
1
  • IDABHF-UCL
Negative regulation of neuron differentiationdefinition[GO:0045665]  
1
  • IDABHF-UCL
Negative regulation of retinoic acid receptor signaling pathwaydefinition[GO:0048387]  
1
  • IDABHF-UCL
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122]  
1
  • IDABHF-UCL
Negative regulation of transcription, DNA-templateddefinition[GO:0045892]  
1
  • IDABHF-UCL
Negative regulation of translationdefinition[GO:0017148]  
2
  • ISSBHF-UCL
Peptide antigen assembly with MHC class I protein complexdefinition[GO:0002502]  
1
  • ISSBHF-UCL
Positive regulation of cell cycledefinition[GO:0045787]  
1
  • IGIBHF-UCL
Positive regulation of cell proliferationdefinition[GO:0008284]  
1
  • IGIBHF-UCL
Positive regulation of dendritic cell chemotaxisdefinition[GO:2000510]  
1
  • IMPUniProtKB
Positive regulation of DNA replicationdefinition[GO:0045740]  
1
  • IGIBHF-UCL
Positive regulation of gene expressiondefinition[GO:0010628] silver  
  • IEAOrtholog Compara
Positive regulation of phagocytosisdefinition[GO:0050766]  
  • ISSOrtholog Curator
Positive regulation of substrate adhesion-dependent cell spreadingdefinition[GO:1900026]  
1
  • IMPUniProtKB
Protein export from nucleusdefinition[GO:0006611]  
1
  • IDAUniProtKB
Protein foldingdefinition[GO:0006457]  
1
  • TASBHF-UCL
Protein localization to nucleusdefinition[GO:0034504]  
1
  • IDAUniProtKB
Protein maturation by protein foldingdefinition[GO:0022417]  
1
  • TASBHF-UCL
Protein stabilizationdefinition[GO:0050821]  
2
  • TASBHF-UCL
  • ISSOrtholog Curator
Regulation of apoptotic processdefinition[GO:0042981]  
1
  • TASUniProtKB
Regulation of meiosisdefinition[GO:0040020] silver  
  • IEAOrtholog Compara
Regulation of transcription, DNA-templateddefinition[GO:0006355]  
1
  • TASPINC
Response to drugdefinition[GO:0042493] silver  
  • IEAOrtholog Compara
Response to estradioldefinition[GO:0032355] silver  
  • IEAOrtholog Compara
Response to testosteronedefinition[GO:0033574] silver  
  • IEAOrtholog Compara
Sequestering of calcium iondefinition[GO:0051208]  
1
  • TASBHF-UCL
Spermatogenesisdefinition[GO:0007283] silver  
  • IEAOrtholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathways:
Antigen processing and presentation  hsa04612+811  
Chagas disease (American trypanosomiasis)  hsa05142+811  
HTLV-I infection  hsa05166+811  
Phagosome  hsa04145+811  
Protein processing in endoplasmic reticulum  hsa04141+811  
According to Reactome, this protein belongs to the following pathways:
Binding and Uptake of Ligands by Scavenger Receptors  REACT_160300  
Immune System  REACT_6900  
Metabolism of proteins  REACT_17015  
Caution 
Was originally (PubMed2332496) thought to be the 52 kDa Ro autoantigen.  
1
  • CuratedUniProtKB
 

Keywords

Molecular function 
Chaperone  definition   [KW-0143]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Calreticulin
GenomeRNAi: 811
PRO: PR:P27797