CANX - Calnexin - human protein (Function)
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CANX »  Calnexin
Protein also known as:  Major histocompatibility complex class I antigen-binding protein p88.
Gene name:  CANX
Family name: Calreticulin
Entry whose protein(s) existence is based on evidence at protein level
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Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor-mediated endocytosis at the synapse.  
  • CuratedUniProtKB
GO molecular function 
Apolipoprotein bindingdefinition[GO:0034185] silver  
  • IEAOrtholog Compara
Calcium ion bindingdefinition[GO:0005509] silver  
  • IEAInterPro 2 GO
Glycoprotein bindingdefinition[GO:0001948] silver  
  • IEAOrtholog Compara
Ionotropic glutamate receptor bindingdefinition[GO:0035255] silver  
  • IEAOrtholog Compara
Poly(A) RNA bindingdefinition[GO:0044822]  
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
  • IPIUniProtKB
  • IPIIntAct
Unfolded protein bindingdefinition[GO:0051082] silver  
  • IEAOrtholog Compara
GO biological process 
Agingdefinition[GO:0007568] silver  
  • IEAOrtholog Compara
Chaperone-mediated protein foldingdefinition[GO:0061077] silver  
  • IEAOrtholog Compara
Clathrin-mediated endocytosisdefinition[GO:0072583]  
  • ISSOrtholog Curator
Protein secretiondefinition[GO:0009306]  
Synaptic vesicle endocytosisdefinition[GO:0048488]  
  • ISSOrtholog Curator
According to KEGG, this protein belongs to the following pathways:
Antigen processing and presentation  hsa04612+821  
HTLV-I infection  hsa05166+821  
Phagosome  hsa04145+821  
Protein processing in endoplasmic reticulum  hsa04141+821  
According to Reactome, this protein belongs to the following pathways:
Antigen Presentation: Folding, assembly and peptide loading of class I MHC  REACT_75795  
Assembly of Viral Components at the Budding Site  REACT_6277  
Calnexin/calreticulin cycle  REACT_23810  
MHC class II antigen presentation  REACT_121399  


Molecular function 
Chaperone  definition   [KW-0143]
Technical term 
Reference proteome  definition   [KW-1185]

Further external links

GeneWiki: Calnexin
GenomeRNAi: 821
PRO: PR:P27824