PIK3R1 - Phosphatidylinositol 3-kinase regulatory subunit alpha - human protein (Function)
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PIK3R1 »  Phosphatidylinositol 3-kinase regulatory subunit alpha  (PI3K regulatory subunit alpha)
Protein also known as:  Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha (PI3-kinase subunit p85-alpha).
Gene name:  PIK3R1
Family name: PI3K p85 subunit
Entry whose protein(s) existence is based on evidence at protein level
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Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling.  
  • CuratedUniProtKB
GO molecular function 
ErbB-3 class receptor bindingdefinition[GO:0043125]  
  • IDAUniProtKB
Insulin bindingdefinition[GO:0043559]  
  • IDAUniProtKB
Insulin receptor bindingdefinition[GO:0005158]  
  • IPIUniProtKB
Insulin receptor substrate bindingdefinition[GO:0043560]  
  • ISSOrtholog Curator
Insulin-like growth factor receptor bindingdefinition[GO:0005159]  
  • IPIUniProtKB
Neurotrophin TRKA receptor bindingdefinition[GO:0005168]  
  • IPIUniProtKB
Phosphatidylinositol 3-kinase bindingdefinition[GO:0043548]  
  • ISSOrtholog Curator
Phosphatidylinositol 3-kinase regulator activitydefinition[GO:0035014]  
  • ISSOrtholog Curator
Protein bindingdefinition[GO:0005515]  
  • IPIIntAct
  • IPIUniProtKB
Protein phosphatase bindingdefinition[GO:0019903]  
  • IPIUniProtKB
Transmembrane receptor protein tyrosine kinase adaptor activitydefinition[GO:0005068]  
  • ISSOrtholog Curator
GO biological process 
B cell differentiationdefinition[GO:0030183] silver  
  • IEAOrtholog Compara
Cellular response to UVdefinition[GO:0034644] silver  
  • IEAOrtholog Compara
Extrinsic apoptotic signaling pathway via death domain receptorsdefinition[GO:0008625] silver  
  • IEAOrtholog Compara
Growth hormone receptor signaling pathwaydefinition[GO:0060396]  
Insulin-like growth factor receptor signaling pathwaydefinition[GO:0048009]  
  • IPIUniProtKB
Intrinsic apoptotic signaling pathway in response to DNA damagedefinition[GO:0008630] silver  
  • IEAOrtholog Compara
Negative regulation of apoptotic processdefinition[GO:0043066] silver  
  • IEAOrtholog Compara
Negative regulation of cell-matrix adhesiondefinition[GO:0001953] silver  
  • IEAOrtholog Compara
Negative regulation of osteoclast differentiationdefinition[GO:0045671] silver  
  • IEAOrtholog Compara
NFAT protein import into nucleusdefinition[GO:0051531] silver  
  • IEAOrtholog Compara
Phosphatidylinositol 3-kinase signalingdefinition[GO:0014065]  
Phosphatidylinositol phosphorylationdefinition[GO:0046854]  
  • ISSOrtholog Curator
Positive regulation of cell migrationdefinition[GO:0030335] silver  
  • IEAOrtholog Compara
Positive regulation of establishment of protein localization to plasma membranedefinition[GO:0090004]  
Positive regulation of glucose importdefinition[GO:0046326]  
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944] silver  
  • IEAOrtholog Compara
Positive regulation of tumor necrosis factor productiondefinition[GO:0032760] silver  
  • IEAOrtholog Compara
Protein phosphorylationdefinition[GO:0006468] silver  
  • IEAOrtholog Compara
Regulation of phosphatidylinositol 3-kinase activitydefinition[GO:0043551]  
  • ISSOrtholog Curator
Viral processdefinition[GO:0016032]  
  • IEAUniProtKB KW
According to KEGG, this protein belongs to the following pathways:
Aldosterone-regulated sodium reabsorption  hsa04960+5295  
Amoebiasis  hsa05146+5295  
Apoptosis  hsa04210+5295  
B cell receptor signaling pathway  hsa04662+5295  
Bacterial invasion of epithelial cells  hsa05100+5295  
Carbohydrate digestion and absorption  hsa04973+5295  
Chagas disease (American trypanosomiasis)  hsa05142+5295  
Chemokine signaling pathway  hsa04062+5295  
Cholinergic synapse  hsa04725+5295  
Chronic myeloid leukemia  hsa05220+5295  
Colorectal cancer  hsa05210+5295  
Endometrial cancer  hsa05213+5295  
ErbB signaling pathway  hsa04012+5295  
Fc epsilon RI signaling pathway  hsa04664+5295  
Fc gamma R-mediated phagocytosis  hsa04666+5295  
Focal adhesion  hsa04510+5295  
Glioma  hsa05214+5295  
Hepatitis C  hsa05160+5295  
HTLV-I infection  hsa05166+5295  
Influenza A  hsa05164+5295  
Insulin signaling pathway  hsa04910+5295  
Jak-STAT signaling pathway  hsa04630+5295  
Leukocyte transendothelial migration  hsa04670+5295  
Measles  hsa05162+5295  
Melanoma  hsa05218+5295  
mTOR signaling pathway  hsa04150+5295  
Natural killer cell mediated cytotoxicity  hsa04650+5295  
Neurotrophin signaling pathway  hsa04722+5295  
Non-small cell lung cancer  hsa05223+5295  
Osteoclast differentiation  hsa04380+5295  
Pancreatic cancer  hsa05212+5295  
Pathways in cancer  hsa05200+5295  
Phosphatidylinositol signaling system  hsa04070+5295  
Progesterone-mediated oocyte maturation  hsa04914+5295  
Prostate cancer  hsa05215+5295  
Regulation of actin cytoskeleton  hsa04810+5295  
Renal cell carcinoma  hsa05211+5295  
Small cell lung cancer  hsa05222+5295  
T cell receptor signaling pathway  hsa04660+5295  
Toll-like receptor signaling pathway  hsa04620+5295  
Toxoplasmosis  hsa05145+5295  
Type II diabetes mellitus  hsa04930+5295  
VEGF signaling pathway  hsa04370+5295  
According to Reactome, this protein belongs to the following pathways:
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers  REACT_118700  
CD28 dependent PI3K/Akt signaling  REACT_19358  
Constitutive PI3K/AKT Signaling in Cancer  REACT_147727  
Costimulation by the CD28 family  REACT_19344  
DAP12 signaling  REACT_147814  
Downstream signal transduction  REACT_17025  
Downstream TCR signaling  REACT_12555  
G alpha (12/13) signalling events  REACT_18407  
G alpha (q) signalling events  REACT_18283  
GAB1 signalosome  REACT_12578  
GP1b-IX-V activation signalling  REACT_23847  
GPVI-mediated activation cascade  REACT_1695  
Interleukin receptor SHC signaling  REACT_23891  
Interleukin-3, 5 and GM-CSF signaling  REACT_23837  
Interleukin-7 signaling  REACT_115529  
Nephrin interactions  REACT_23832  
PI-3K cascade  REACT_21270  
PI3K Cascade  REACT_976  
PI3K events in ERBB2 signaling  REACT_116008  
PI3K events in ERBB4 signaling  REACT_115961  
PI3K/AKT activation  REACT_12464  
PIP3 activates AKT signaling  REACT_75829  
Regulation of signaling by CBL  REACT_23787  
Role of LAT2/NTAL/LAB on calcium mobilization  REACT_163769  
Role of phospholipids in phagocytosis  REACT_160158  
Signaling by constitutively active EGFR  REACT_115852  
Signaling by FGFR mutants  REACT_121398  
Signaling by FGFR1 fusion mutants  REACT_121141  
Signaling by SCF-KIT  REACT_111040  
Synthesis of PIPs at the plasma membrane  REACT_121025  
Tie2 Signaling  REACT_12621  
More information is available from:


Biological process 
Host-virus interaction  definition   [KW-0945]
Technical term 
Reference proteome  definition   [KW-1185]

Further external links

GeneWiki: PIK3R1
GenomeRNAi: 5295
PRO: PR:P27986