PIK3R1 - Phosphatidylinositol 3-kinase regulatory subunit alpha - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Protein
Gene
References

 
PIK3R1 »  Phosphatidylinositol 3-kinase regulatory subunit alpha  (PI3K regulatory subunit alpha)
 
Protein also known as:  Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha (PI3-kinase subunit p85-alpha).
Gene name:  PIK3R1
Family name: PI3K p85 subunit
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 318 5
GENE REF ISO

Function

 show evidences
Overview 
Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling (PubMed17626883, PubMed19805105, PubMed7518429). Modulates the cellular response to ER stress by promoting nuclear translocation of XBP1 isoform 2 in a ER stress-and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement (PubMed20348923).  
5
  • UniProtKB
GO molecular function 
1-phosphatidylinositol-3-kinase regulator activitydefinition[GO:0046935]  
1
  • RefGenome
ErbB-3 class receptor bindingdefinition[GO:0043125]  
1
  • UniProtKB
Insulin bindingdefinition[GO:0043559]  
1
  • UniProtKB
Insulin receptor bindingdefinition[GO:0005158]  
1
  • UniProtKB
Insulin receptor substrate bindingdefinition[GO:0043560]  
1
  • Ortholog Curator
Insulin-like growth factor receptor bindingdefinition[GO:0005159]  
1
  • UniProtKB
Neurotrophin TRKA receptor bindingdefinition[GO:0005168]  
1
  • UniProtKB
Phosphatidylinositol 3-kinase bindingdefinition[GO:0043548]  
1
  • Ortholog Curator
Phosphatidylinositol 3-kinase regulator activitydefinition[GO:0035014]  
1
  • Ortholog Curator
Phosphatidylinositol 3-kinase regulatory subunit bindingdefinition[GO:0036312] silver  
1
  • Ortholog Compara
Protein bindingdefinition[GO:0005515]  
88
  • IntAct
  • UniProtKB
  • BHF-UCL
Protein heterodimerization activitydefinition[GO:0046982] silver  
1
  • Ortholog Compara
Protein phosphatase bindingdefinition[GO:0019903]  
1
  • UniProtKB
Transcription factor bindingdefinition[GO:0008134]  
1
  • UniProtKB
Transmembrane receptor protein tyrosine kinase adaptor activitydefinition[GO:0005068]  
1
  • Ortholog Curator
GO biological process 
B cell differentiationdefinition[GO:0030183] silver  
1
  • Ortholog Compara
Cellular glucose homeostasisdefinition[GO:0001678]  
1
  • Ortholog Curator
Cellular response to insulin stimulusdefinition[GO:0032869]  
1
  • Ortholog Curator
Cellular response to UVdefinition[GO:0034644] silver  
1
  • Ortholog Compara
Extrinsic apoptotic signaling pathway via death domain receptorsdefinition[GO:0008625] silver  
1
  • Ortholog Compara
Growth hormone receptor signaling pathwaydefinition[GO:0060396]  
1
  • BHF-UCL
Insulin receptor signaling pathwaydefinition[GO:0008286]  
1
  • RefGenome
Insulin-like growth factor receptor signaling pathwaydefinition[GO:0048009]  
2
  • UniProtKB
  • BHF-UCL
Intrinsic apoptotic signaling pathway in response to DNA damagedefinition[GO:0008630] silver  
1
  • Ortholog Compara
Negative regulation of apoptotic processdefinition[GO:0043066]  
1
  • UniProtKB
Negative regulation of cell-matrix adhesiondefinition[GO:0001953] silver  
1
  • Ortholog Compara
Negative regulation of osteoclast differentiationdefinition[GO:0045671] silver  
1
  • Ortholog Compara
NFAT protein import into nucleusdefinition[GO:0051531] silver  
1
  • Ortholog Compara
Phosphatidylinositol 3-kinase signalingdefinition[GO:0014065]  
1
  • BHF-UCL
Phosphatidylinositol phosphorylationdefinition[GO:0046854]  
2
  • Ortholog Curator
  • RefGenome
Positive regulation of cell migrationdefinition[GO:0030335] silver  
1
  • Ortholog Compara
Positive regulation of endoplasmic reticulum unfolded protein responsedefinition[GO:1900103]  
1
  • UniProtKB
Positive regulation of establishment of protein localization to plasma membranedefinition[GO:0090004]  
1
  • BHF-UCL
Positive regulation of glucose importdefinition[GO:0046326]  
1
  • BHF-UCL
Isoform  Iso 4   Positive regulation of glucose import in response to insulin stimulusdefinition[GO:2001275]  
1
  • Ortholog Curator
Positive regulation of RNA splicingdefinition[GO:0033120]  
1
  • UniProtKB
Positive regulation of transcription factor import into nucleusdefinition[GO:0042993]  
2
  • UniProtKB
  • Ortholog Curator
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
2
  • UniProtKB
  • Ortholog Curator
Positive regulation of tumor necrosis factor productiondefinition[GO:0032760] silver  
1
  • Ortholog Compara
Protein phosphorylationdefinition[GO:0006468] silver  
1
  • Ortholog Compara
Protein stabilizationdefinition[GO:0050821]  
1
  • UniProtKB
Regulation of phosphatidylinositol 3-kinase activitydefinition[GO:0043551]  
2
  • RefGenome
  • Ortholog Curator
Regulation of stress fiber assemblydefinition[GO:0051492] silver  
1
  • Ortholog Compara
Response to endoplasmic reticulum stressdefinition[GO:0034976]  
2
  • UniProtKB
  • Ortholog Curator
Viral processdefinition[GO:0016032]  
1
  • UniProtKB KW
Enzymatic activity 
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Aldosterone-regulated sodium reabsorption  hsa04960+5295  
Amoebiasis  hsa05146+5295  
Apoptosis  hsa04210+5295  
B cell receptor signaling pathway  hsa04662+5295  
Bacterial invasion of epithelial cells  hsa05100+5295  
Carbohydrate digestion and absorption  hsa04973+5295  
Chagas disease (American trypanosomiasis)  hsa05142+5295  
Chemokine signaling pathway  hsa04062+5295  
Cholinergic synapse  hsa04725+5295  
Chronic myeloid leukemia  hsa05220+5295  
Colorectal cancer  hsa05210+5295  
Endometrial cancer  hsa05213+5295  
ErbB signaling pathway  hsa04012+5295  
Fc epsilon RI signaling pathway  hsa04664+5295  
Fc gamma R-mediated phagocytosis  hsa04666+5295  
Focal adhesion  hsa04510+5295  
Glioma  hsa05214+5295  
Hepatitis C  hsa05160+5295  
HTLV-I infection  hsa05166+5295  
Influenza A  hsa05164+5295  
Insulin signaling pathway  hsa04910+5295  
Jak-STAT signaling pathway  hsa04630+5295  
Leukocyte transendothelial migration  hsa04670+5295  
Measles  hsa05162+5295  
Melanoma  hsa05218+5295  
mTOR signaling pathway  hsa04150+5295  
Natural killer cell mediated cytotoxicity  hsa04650+5295  
Neurotrophin signaling pathway  hsa04722+5295  
Non-small cell lung cancer  hsa05223+5295  
Osteoclast differentiation  hsa04380+5295  
Pancreatic cancer  hsa05212+5295  
Pathways in cancer  hsa05200+5295  
Phosphatidylinositol signaling system  hsa04070+5295  
Progesterone-mediated oocyte maturation  hsa04914+5295  
Prostate cancer  hsa05215+5295  
Regulation of actin cytoskeleton  hsa04810+5295  
Renal cell carcinoma  hsa05211+5295  
Small cell lung cancer  hsa05222+5295  
T cell receptor signaling pathway  hsa04660+5295  
Toll-like receptor signaling pathway  hsa04620+5295  
Toxoplasmosis  hsa05145+5295  
Type II diabetes mellitus  hsa04930+5295  
VEGF signaling pathway  hsa04370+5295  
According to Reactome, this protein belongs to the following pathways:
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers  R-HSA-983695  
CD28 dependent PI3K/Akt signaling  R-HSA-389357  
Constitutive Signaling by Aberrant PI3K in Cancer  R-HSA-2219530  
Constitutive Signaling by EGFRvIII  R-HSA-5637810  
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants  R-HSA-1236382  
Costimulation by the CD28 family  R-HSA-388841  
DAP12 signaling  R-HSA-2424491  
Downstream signal transduction  R-HSA-186763  
Downstream TCR signaling  R-HSA-202424  
G alpha (12/13) signalling events  R-HSA-416482  
G alpha (q) signalling events  R-HSA-416476  
G beta:gamma signalling through PI3Kgamma  R-HSA-392451  
GAB1 signalosome  R-HSA-180292  
GP1b-IX-V activation signalling  R-HSA-430116  
GPVI-mediated activation cascade  R-HSA-114604  
Interleukin receptor SHC signaling  R-HSA-912526  
Interleukin-3, 5 and GM-CSF signaling  R-HSA-512988  
Interleukin-7 signaling  R-HSA-1266695  
Nephrin interactions  R-HSA-373753  
PI-3K cascade:FGFR1  R-HSA-5654689  
PI-3K cascade:FGFR2  R-HSA-5654695  
PI-3K cascade:FGFR3  R-HSA-5654710  
PI-3K cascade:FGFR4  R-HSA-5654720  
PI3K Cascade  R-HSA-109704  
PI3K events in ERBB2 signaling  R-HSA-1963642  
PI3K events in ERBB4 signaling  R-HSA-1250342  
PI3K/AKT activation  R-HSA-198203  
PIP3 activates AKT signaling  R-HSA-1257604  
Regulation of signaling by CBL  R-HSA-912631  
Role of LAT2/NTAL/LAB on calcium mobilization  R-HSA-2730905  
Role of phospholipids in phagocytosis  R-HSA-2029485  
Signaling by FGFR1 fusion mutants  R-HSA-1839117  
Signaling by FGFR1 in disease  R-HSA-5655302  
Signaling by FGFR2 in disease  R-HSA-5655253  
Signaling by FGFR3 in disease  R-HSA-5655332  
Signaling by FGFR4 in disease  R-HSA-5655291  
Signaling by SCF-KIT  R-HSA-1433557  
Synthesis of PIPs at the plasma membrane  R-HSA-1660499  
Tie2 Signaling  R-HSA-210993  
VEGFA-VEGFR2 Pathway  R-HSA-4420097  
 
More information is available from:
 

Keywords

Biological process 
Host-virus interaction  definition   [KW-0945]
Protein transport  definition   [KW-0653]
Stress response  definition   [KW-0346]
Transport  definition   [KW-0813]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: PIK3R1
GenomeRNAi: 5295
PRO: PR:P27986