PSMB8 - Proteasome subunit beta type-8 - human protein (Function)
 
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PSMB8 »  Proteasome subunit beta type-8   [ EC 3.4.25.1 ]
 
Protein also known as:  Multicatalytic endopeptidase complex subunit C13.
Gene name:  PSMB8
Family name: Peptidase T1B
Entry whose protein(s) existence is based on evidence at protein level
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Function

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Overview 
The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides. Replacement of PSMB5 by PSMB8 increases the capacity of the immunoproteasome to cleave model peptides after hydrophobic and basic residues. Acts as a major component of interferon gamma-induced sensitivity. Plays a key role in apoptosis via the degradation of the apoptotic inhibitor MCL1. May be involved in the inflammatory response pathway. In cancer cells, substitution of isoform 1 (E2) by isoform 2 (E1) results in immunoproteasome deficiency. Required for the differentiation of preadipocytes into adipocytes.  
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  • CuratedUniProtKB
GO molecular function 
Protein bindingdefinition[GO:0005515]  
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  • IPIIntAct
Threonine-type endopeptidase activitydefinition[GO:0004298]  
  • IEAUniProtKB KW
GO biological process 
Fat cell differentiationdefinition[GO:0045444]  
1
  • IMPUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.4.25.1: Cleavage of peptide bonds with very broad specificity.  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathway:
Proteasome  hsa03050+5696  
According to Reactome, this protein belongs to the following pathways:
Apoptosis  REACT_578  
Cdc20:Phospho-APC/C mediated degradation of Cyclin A  REACT_6850  
Cell Cycle  REACT_115566  
Disease  REACT_116125  
DNA Replication  REACT_383  
Gene Expression  REACT_71  
Immune System  REACT_6900  
Metabolism  REACT_111217  
Metabolism of RNA  REACT_21257  
Mitotic M-M/G1 phases  REACT_21300  
Proteasome mediated degradation of PAK-2p34  REACT_13505  
Signal Transduction  REACT_111102  
 

Keywords

Biological process 
Differentiation  definition   [KW-0221]
Host-virus interaction  definition   [KW-0945]
Immunity  definition   [KW-0391]
Molecular function 
Hydrolase  definition   [KW-0378]
Protease  definition   [KW-0645]
Threonine protease  definition   [KW-0888]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: PSMB8
GenomeRNAi: 5696
PRO: PR:P28062