PSMB8 - Proteasome subunit beta type-8 - human protein (Function)
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PSMB8 »  Proteasome subunit beta type-8   [ EC ]
Protein also known as:  Multicatalytic endopeptidase complex subunit C13.
Gene name:  PSMB8
Family name: Peptidase T1B
Entry whose protein(s) existence is based on evidence at protein level
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The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides. Replacement of PSMB5 by PSMB8 increases the capacity of the immunoproteasome to cleave model peptides after hydrophobic and basic residues. Acts as a major component of interferon gamma-induced sensitivity. Plays a key role in apoptosis via the degradation of the apoptotic inhibitor MCL1. May be involved in the inflammatory response pathway. In cancer cells, substitution of isoform 1 (E2) by isoform 2 (E1) results in immunoproteasome deficiency. Required for the differentiation of preadipocytes into adipocytes.  
  • UniProtKB
GO molecular function 
Protein bindingdefinition[GO:0005515]  
  • IntAct
Threonine-type endopeptidase activitydefinition[GO:0004298]  
  • UniProtKB KW
GO biological process 
Fat cell differentiationdefinition[GO:0045444]  
  • UniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC Cleavage of peptide bonds with very broad specificity.  
  • UniProtKB
More information is available from:
According to KEGG, this protein belongs to the following pathway:
Proteasome  hsa03050+5696  
According to Reactome, this protein belongs to the following pathways:
Activation of NF-kappaB in B cells  REACT_118656  
Antigen processing: Ubiquitination & Proteasome degradation  REACT_75842  
APC/C:Cdc20 mediated degradation of Securin  REACT_6871  
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1  REACT_6761  
Asymmetric localization of PCP proteins  REACT_172638  
AUF1 (hnRNP D0) destabilizes mRNA  REACT_25325  
Autodegradation of Cdh1 by Cdh1:APC/C  REACT_6785  
Autodegradation of the E3 ubiquitin ligase COP1  REACT_20549  
CDK-mediated phosphorylation and removal of Cdc6  REACT_1221  
CDT1 association with the CDC6:ORC:origin complex  REACT_1949  
Cross-presentation of soluble exogenous antigens (endosomes)  REACT_111056  
degradation of AXIN  REACT_200766  
Degradation of beta-catenin by the destruction complex  REACT_11063  
degradation of DVL  REACT_200841  
Degradation of GLI1 by the proteasome  REACT_267605  
Degradation of GLI2 by the proteasome  REACT_206597  
ER-Phagosome pathway  REACT_111178  
GLI3 is processed to GLI3R by the proteasome  REACT_231645  
Hedgehog ligand biogenesis  REACT_228111  
Hh ligand biogenesis disease  REACT_228209  
Interferon alpha/beta signaling  REACT_25162  
Orc1 removal from chromatin  REACT_1156  
Regulation of activated PAK-2p34 by proteasome mediated degradation  REACT_13464  
Regulation of ornithine decarboxylase (ODC)  REACT_13565  
SCF(Skp2)-mediated degradation of p27/p21  REACT_9003  
SCF-beta-TrCP mediated degradation of Emi1  REACT_6821  
Separation of Sister Chromatids  REACT_150471  
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A  REACT_1614  
Ubiquitin-dependent degradation of Cyclin D1  REACT_4  
Vif-mediated degradation of APOBEC3G  REACT_9453  
Vpu mediated degradation of CD4  REACT_9031  


Biological process 
Differentiation  definition   [KW-0221]
Host-virus interaction  definition   [KW-0945]
Immunity  definition   [KW-0391]
Molecular function 
Hydrolase  definition   [KW-0378]
Protease  definition   [KW-0645]
Threonine protease  definition   [KW-0888]
Technical term 
Reference proteome  definition   [KW-1185]

Further external links

GeneWiki: PSMB8
GenomeRNAi: 5696
PRO: PR:P28062