POU1F1 - Pituitary-specific positive transcription factor 1 - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
POU1F1 »  Pituitary-specific positive transcription factor 1  (PIT-1)
 
Protein also known as:  Growth hormone factor 1 (GHF-1).
Gene name:  POU1F1
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 76 2
GENE REF ISO

Function

 show evidences
Overview 
Transcription factor involved in the specification of the lactotrope, somatotrope, and thyrotrope phenotypes in the developing anterior pituitary. Activates growth hormone and prolactin genes. Specifically binds to the consensus sequence 5'-TAAAT-3'.  
1
  • UniProtKB
GO molecular function 
Chromatin bindingdefinition[GO:0003682] silver  
1
  • Ortholog Compara
RNA polymerase II activating transcription factor bindingdefinition[GO:0001102]  
2
  • BHF-UCL
RNA polymerase II core promoter proximal region sequence-specific DNA bindingdefinition[GO:0000978] silver  
1
  • Ortholog Compara
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptiondefinition[GO:0001077] silver  
1
  • Ortholog Compara
RNA polymerase II transcription coactivator activitydefinition[GO:0001105]  
1
  • BHF-UCL
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700]  
1
  • BHF-UCL
Transcription corepressor activitydefinition[GO:0003714] silver  
1
  • Ortholog Compara
GO biological process 
B cell differentiationdefinition[GO:0030183] silver  
1
  • Ortholog Compara
Cell fate specificationdefinition[GO:0001708] silver  
1
  • Ortholog Compara
Determination of adult lifespandefinition[GO:0008340] silver  
1
  • Ortholog Compara
Negative regulation of cell proliferationdefinition[GO:0008285]  
1
  • PINC
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122] silver  
1
  • Ortholog Compara
Nuclear transportdefinition[GO:0051169] silver  
1
  • Ortholog Compara
Positive regulation of cell proliferationdefinition[GO:0008284] silver  
1
  • Ortholog Compara
Positive regulation of inositol trisphosphate biosynthetic processdefinition[GO:0032962] silver  
1
  • Ortholog Compara
Positive regulation of multicellular organism growthdefinition[GO:0040018] silver  
1
  • Ortholog Compara
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
1
  • BHF-UCL
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
1
  • BHF-UCL
Regulation of insulin-like growth factor receptor signaling pathwaydefinition[GO:0043567] silver  
1
  • Ortholog Compara
Somatotropin secreting cell developmentdefinition[GO:0060133] silver  
1
  • Ortholog Compara
Transcription from RNA polymerase II promoterdefinition[GO:0006366]  
1
  • PINC
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Activator  definition   [KW-0010]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links