HTR1D - 5-hydroxytryptamine receptor 1D - human protein (Function)
 
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HTR1D »  5-hydroxytryptamine receptor 1D
 
Gene name:  HTR1D
Entry whose protein(s) existence is based on evidence at protein level
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1 29 1
GENE REF ISO

Function

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Overview 
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Regulates the release of 5-hydroxytryptamine in the brain, and thereby affects neural activity. May also play a role in regulating the release of other neurotransmitters. May play a role in vasoconstriction.  
3
  • CuratedUniProtKB
GO molecular function 
Serotonin bindingdefinition[GO:0051378] silver  
  • IEAOrtholog Compara
Serotonin receptor activitydefinition[GO:0004993]  
1
  • IMPUniProtKB
GO biological process 
Adenylate cyclase-inhibiting G-protein coupled receptor signaling pathwaydefinition[GO:0007193]  
1
  • IMPUniProtKB
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerdefinition[GO:0007187]  
1
  • TASPINC
Intestine smooth muscle contractiondefinition[GO:0014827]  
1
  • IMPUniProtKB
Regulation of behaviordefinition[GO:0050795] silver  
  • IEAInterPro 2 GO
Regulation of locomotiondefinition[GO:0040012] silver  
  • IEAInterPro 2 GO
Response to toxic substancedefinition[GO:0009636] silver  
  • IEAOrtholog Compara
Serotonin receptor signaling pathwaydefinition[GO:0007210] silver  
  • IEAOrtholog Compara
Synaptic transmissiondefinition[GO:0007268] silver  
  • IEAInterPro 2 GO
Vasoconstrictiondefinition[GO:0042310] silver  
  • IEAInterPro 2 GO
Pathways 
According to KEGG, this protein belongs to the following pathway:
Neuroactive ligand-receptor interaction  hsa04080+3352  
According to Reactome, this protein belongs to the following pathways:
G alpha (i) signalling events  REACT_19231  
Serotonin receptors  REACT_17064  
 

Keywords

Molecular function 
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: 5-HT1D_receptor
GenomeRNAi: 3352
PRO: PR:P28221
Chemistry
GuidetoPHARMACOLOGY: 3